Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| T47D | HY-17541A | 72 | 6.09725713645 | -0.5568 | 0.3223 | 17.5481 | -1.0000 | 1.0393 |
| T47D | HY-50737A | 72 | 4.05537288518 | -0.2242 | 0.3936 | 4.4286 | -0.2752 | 4.9803 |
| T47D | IU1 | 72 | inf | 0.5230 | 0.0543 | 0.0000 | 0.9042 | 0.0100 |
| T47D | MI-2 | 72 | 0.443682151865 | -0.4886 | 0.7738 | 0.5068 | -0.4479 | 4.8114 |
| T47D | ML-323 | 72 | 13.4276900688 | 0.0649 | 0.2011 | 60.0348 | -0.9911 | 0.7296 |
| T47D | USP7-IN-1 | 72 | 35.2358506575 | 0.3921 | 0.1491 | 300.7608 | -1.0000 | 0.5124 |
| T47D | SB1-F-21 | 72 | 0.605682620995 | -0.5948 | 0.6994 | 0.9625 | -0.5534 | 1.6087 |
| SK-BR-3 | PB49673382 | 72 | 4.13146034734 | 0.0664 | 0.3312 | 3.9132 | 0.0565 | 2.2078 |
| SK-BR-3 | Pevonedistat | 72 | 0.0849225267347 | 0.0282 | 0.7128 | 0.0790 | 0.0487 | 1.4169 |
| SK-BR-3 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9496 | 0.0325 | 0.0000 | 0.9679 | 0.0100 |
| SK-BR-3 | IU1 | 72 | 206.741150231 | 0.7547 | 0.0343 | 99.4820 | 0.2546 | 0.9732 |
| SK-BR-3 | HY-17542 | 72 | inf | 0.8550 | 0.0387 | 0.0000 | 0.9480 | 0.0100 |
| SK-BR-3 | LDN57444 | 72 | 22.3408232354 | 0.2285 | 0.1807 | 104.9983 | -1.0000 | 0.7099 |
| SK-BR-3 | USP7-IN-1 | 72 | 62.2210904101 | 0.5764 | 0.0588 | 133.0943 | -1.0000 | 1.4449 |
| SK-BR-3 | 1247825-37-1 | 72 | 8.5852333914 | -0.0647 | 0.2610 | 8.9503 | -0.0631 | 2.8528 |
| SK-BR-3 | GW7647 | 72 | 63.3177975853 | 0.6434 | 0.0223 | 112.2791 | -1.0000 | 1.9179 |
| SK-BR-3 | MI-2 | 72 | 0.671480855708 | -0.7413 | 0.8062 | 0.9689 | -0.7037 | 2.3958 |
| SK-BR-3 | HBX 41108 | 72 | 0.707551662904 | -0.6033 | 0.6328 | 2.3097 | -0.7141 | 0.7499 |
| SK-BR-3 | HY-17541A | 72 | 6.05256867179 | -0.8127 | 0.3348 | 15.3356 | -1.0000 | 1.1817 |
| SK-BR-3 | HY-50736 | 72 | 0.115680810144 | -0.4176 | 0.9862 | 0.1504 | -0.4466 | 2.4308 |
| SK-BR-3 | HY-50737A | 72 | 0.478741799562 | -0.5895 | 0.7685 | 0.6829 | -0.5240 | 2.0185 |
| SK-BR-3 | HBX19818 | 72 | 16.5240512414 | -0.5295 | 0.1906 | 30.2429 | -1.0000 | 1.8176 |
| SK-BR-3 | Trifluoperazine | 72 | 8.87780846384 | -0.7359 | 0.3201 | 12.7153 | -0.8135 | 2.6884 |
| SK-BR-3 | z-VAE(OMe)-fmk | 72 | inf | 0.9573 | 0.0430 | 0.0000 | 0.9575 | 0.0100 |
| SK-BR-3 | Mitoxantrone | 72 | 0.00831816680715 | -0.7263 | 1.2354 | 0.0647 | -0.7477 | 0.4458 |