Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAL-85-1 INK-128
mTORC1/2
PI3K/mTOR
0.0088347
 0.0160 0.6258 0.0624 1.3592
0.0084516
0.99836
CAL-85-1 PF-4708671
p70S6K
PI3K/mTOR
Inf
 1.0208 -0.0232 0.0035 0.0000
Inf
-0.61108
CAL-85-1 Buparlisib
pan PI3K
PI3K/mTOR
0.34255
 -0.3199 0.4420 0.1137 0.9213
0.69609
0.99686
CAL-85-1 Pictilisib
pan PI3K
PI3K/mTOR
0.64687
 -0.0252 0.3599 0.0411 0.3938
10.5271
0.97679
CAL-85-1 Ceritinib
ALK
RTK
0.74024
 -0.5961 0.3725 0.0586 0.9797
2.2143
0.9988
CAL-85-1 Neratinib
EGFR/HER2
RTK
0.033863
 -0.3264 0.5379 0.1694 0.6592
0.072972
0.9766
CAL-85-1 Tivantinib
MET
RTK
0.19824
 -0.3263 0.5188 0.1982 1.5649
0.27534
0.99663
CAL-85-1 Cediranib
VEGFR/cKIT
RTK
2.4003
 -0.2379 0.1869 0.0514 1.1002
6.5151
0.99569
CAL-85-1 Cabozantinib
VEGFR2/MET
RTK
5.3386
 0.1728 0.1229 0.0278 1.1624
13.7367
0.96943
HCC1143 Abemaciclib
CDK4/6
Cell cycle
0.07025
 -0.0787 0.5407 0.0153 0.5300
0.09592
0.97963
HCC1143 Palbociclib
CDK4/6
Cell cycle
0.27702
 0.2820 0.2546 -0.0033 0.9158
0.11143
0.98993
HCC1143 AZD7762
CHK1/2
Cell cycle
0.05422
 -0.3693 0.6563 0.2192 1.8612
0.067869
0.988
HCC1143 Volasertib
PLK
Cell cycle
0.0045882
 -0.3453 0.7290 0.2418 1.8336
0.005996
0.99928
HCC1143 Dinaciclib
pan CDK
Cell cycle
0.015148
 -0.2527 0.5451 0.1106 5.0000
0.016398
0.9989
HCC1143 Cisplatin
Chemo
Chemotherapy
0.83695
 0.0754 0.3041 0.0403 1.3278
0.83273
0.96685
HCC1143 Doxorubicin
Chemo
Chemotherapy
0.0092688
 -0.2511 0.7180 0.1402 1.1622
0.012302
0.98917
HCC1143 Taxol
Chemo
Chemotherapy
0.0020688
 -0.3349 0.8388 0.3074 2.5955
0.0024565
0.99279
HCC1143 Topotecan
Topo I
Chemotherapy
0.0094142
 -0.4304 0.9040 0.3002 1.1711
0.013874
0.94725
HCC1143 Etoposide
Topo II
Chemotherapy
0.46267
 -0.1664 0.3837 0.1279 1.8259
0.55287
0.99758
HCC1143 Dasatinib
BCR/ABL
MAPK/nRTK
0.13934
 0.2573 0.4469 0.1044 0.5121
0.046932
0.96213
HCC1143 Trametinib
MEK
MAPK/nRTK
0.0088297
 -0.0225 0.5379 0.1187 0.5756
0.013291
0.99613
HCC1143 Saracatinib
SRC
MAPK/nRTK
3.0304
 0.3881 0.2375 0.0437 0.4638
1.6973
0.97807
HCC1143 ABT-737
Bcl2/XL
Misc
6.1992
 0.3758 0.1027 0.0110 0.8672
8.5825
0.98522
HCC1143 Vorinostat
HDAC
Misc
0.91041
 -0.2533 0.2953 0.0977 1.9423
1.1249
0.99293
HCC1143 Luminespib
HSP90
Misc
0.0039434
 -0.1922 0.7017 0.1659 3.6671
0.0042921
0.99512