Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAL-120 Etoposide
Topo II
Chemotherapy
0.47956
 -0.1663 0.3810 0.0949 1.2763
0.62593
0.99712
CAL-120 Dasatinib
BCR/ABL
MAPK/nRTK
0.049579
 0.1763 0.5193 0.0672 1.3302
0.036844
0.97412
CAL-120 Trametinib
MEK
MAPK/nRTK
0.046732
 0.4153 0.2938 0.0276 1.2901
0.011053
0.98433
CAL-120 Saracatinib
SRC
MAPK/nRTK
15.6396
 0.5261 0.1730 0.0078 0.3429
33.0327
0.96689
CAL-120 ABT-737
Bcl2/XL
Misc
2.1471
 -0.4339 0.1998 0.1107 1.5326
3.968
0.99796
CAL-120 Vorinostat
HDAC
Misc
1.3545
 -0.2281 0.2409 0.0682 1.2739
2.1265
0.9951
CAL-120 Luminespib
HSP90
Misc
0.0028134
 -0.1149 0.6933 0.1709 1.6073
0.0031386
0.99357
CAL-120 A-1210477
Mcl-1
Misc
Inf
 0.9427 0.0152 0.0003 0.0000
Inf
0.34764
CAL-120 Olaparib
PARP
Misc
5.1241
 0.2688 0.1427 0.0159 0.7347
22.8567
0.97745
CAL-120 Bleomycin
Radiation
Misc
1.687
 0.0886 0.2320 0.0671 0.8116
2.7215
0.99732
CAL-120 Ipatasertib
AKT
PI3K/mTOR
58.682
 0.5993 0.1297 -0.0033 0.4437
5.6283
0.9635
CAL-120 Alpelisib
PI3Ka
PI3K/mTOR
21.5328
 0.6075 0.0922 -0.0015 0.5034
190.956
0.93579
CAL-120 Taselisib
PI3Ka, g, d
PI3K/mTOR
2.5327
 0.1514 0.2349 0.0129 0.4887
23.9822
0.95866
CAL-120 TGX221
PI3Kb
PI3K/mTOR
Inf
 1.0198 -0.0168 -0.0059 0.0000
Inf
-0.45144
CAL-120 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.010544
 -0.0115 0.4872 0.0485 1.2658
0.010318
0.99716
CAL-120 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.5275 0.4163 -0.0050 0.1797
1.1993e-05
0.81569
CAL-120 INK-128
mTORC1/2
PI3K/mTOR
0.011487
 -0.0097 0.6018 0.0545 1.3448
0.011154
0.99759
CAL-120 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.9240 0.0139 -0.0025 0.0000
Inf
0.39826
CAL-120 Buparlisib
pan PI3K
PI3K/mTOR
0.70223
 -0.2717 0.3393 0.0962 0.9615
1.3908
0.99923
CAL-120 Pictilisib
pan PI3K
PI3K/mTOR
2.072
 0.1944 0.2550 0.0144 0.4073
30.7541
0.99232
CAL-120 Ceritinib
ALK
RTK
0.79939
 -0.4322 0.3366 0.1170 1.0290
1.7983
0.99115
CAL-120 Neratinib
EGFR/HER2
RTK
0.59003
 -0.2607 0.2238 0.0655 0.9310
1.9202
0.98923
CAL-120 Tivantinib
MET
RTK
0.25132
 -0.2562 0.4649 0.1572 1.1267
0.37355
0.99876
CAL-120 Cediranib
VEGFR/cKIT
RTK
1.037
 -0.1243 0.2989 0.0564 0.5757
6.9922
0.99099
CAL-120 Cabozantinib
VEGFR2/MET
RTK
7.3417
 0.2574 0.0848 0.0071 1.8478
13.277
0.98262