Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1258 Buparlisib
pan PI3K
PI3K/mTOR
1.3631
 -0.3924 0.2516 0.0862 1.2064
2.8058
0.99443
MCF 10A Buparlisib
pan PI3K
PI3K/mTOR
1.465
 -0.1604 0.2493 0.0444 1.6479
1.8654
0.99356
HCC1500 Buparlisib
pan PI3K
PI3K/mTOR
0.20179
 -0.5459 0.5351 0.1146 0.8962
0.51424
0.99364
SUM1315MO2 Buparlisib
pan PI3K
PI3K/mTOR
0.40124
 -0.3686 0.4388 0.1149 0.9148
0.94031
0.98014
CAL-85-1 Buparlisib
pan PI3K
PI3K/mTOR
0.34255
 -0.3199 0.4420 0.1137 0.9213
0.69609
0.99686
MDA-MB-436 Buparlisib
pan PI3K
PI3K/mTOR
1.1815
 -0.2866 0.2925 0.0578 1.6196
1.6556
0.99244
Hs 578T Buparlisib
pan PI3K
PI3K/mTOR
0.68631
 -0.3434 0.3760 0.1520 1.4596
1.0562
0.9918
HME1 Buparlisib
pan PI3K
PI3K/mTOR
1.1504
 -0.2416 0.2469 0.0826 1.9615
1.4311
0.99598
SUM149PT Buparlisib
pan PI3K
PI3K/mTOR
1.4121
 -0.3357 0.2539 0.1216 1.9093
1.9133
0.99941
MDA-MB-231 Buparlisib
pan PI3K
PI3K/mTOR
1.5103
 -0.2351 0.2751 0.0596 1.9855
1.8969
0.98328
BT-549 Buparlisib
pan PI3K
PI3K/mTOR
1.419
 -0.2716 0.2487 0.0802 2.0178
1.8107
0.99484
MDA-MB-361 Buparlisib
pan PI3K
PI3K/mTOR
0.21797
 -0.9584 0.6114 0.1763 0.9709
0.67584
0.99384
MDA-MB-134-VI Buparlisib
pan PI3K
PI3K/mTOR
0.15425
 -0.8251 0.6432 0.1617 0.9833
0.45209
0.98862
HCC1419 Buparlisib
pan PI3K
PI3K/mTOR
0.39623
 -0.4961 0.4499 0.0745 0.8204
1.2651
0.99188
HCC1428 Buparlisib
pan PI3K
PI3K/mTOR
0.69074
 -0.2646 0.3524 0.1087 1.9122
0.88637
0.99206
MDA-MB-468 Buparlisib
pan PI3K
PI3K/mTOR
0.83168
 -0.5157 0.3573 0.2010 2.1267
1.1738
0.99824
PDXHCI002 Buparlisib
pan PI3K
PI3K/mTOR
1.4379
 -0.4797 0.2447 0.1228 3.2385
1.7721
0.99509
MDA-MB-453 Buparlisib
pan PI3K
PI3K/mTOR
0.69073
 -0.6073 0.3442 0.1124 1.2215
1.4247
0.9883
HCC1937 Buparlisib
pan PI3K
PI3K/mTOR
1.4479
 -0.2256 0.2634 0.0691 1.0878
2.8639
0.99474
MCF7 Buparlisib
pan PI3K
PI3K/mTOR
0.18746
 -0.2690 0.5035 0.1162 0.8936
0.34198
0.99189
CAMA-1 Cabozantinib
VEGFR2/MET
RTK
8.7107
 0.2436 0.0342 0.0090 4.9963
10.1282
0.97965
SUM149PT Cabozantinib
VEGFR2/MET
RTK
5.7589
 0.2895 0.0383 0.0198 4.7896
4.9143
0.99303
PDXHCI002 Cabozantinib
VEGFR2/MET
RTK
7.2097
 0.2341 0.0443 0.0248 1.8969
12.8614
0.98302
HCC1954 Cabozantinib
VEGFR2/MET
RTK
10.9106
 0.6390 -0.0135 -0.0074 5.0000
13.0234
0.87916
BT-20 Cabozantinib
VEGFR2/MET
RTK
5.3516
 -0.2030 0.0566 0.0432 4.9846
5.8613
0.99079