Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SK-BR-3 Cabozantinib
VEGFR2/MET
RTK
9.7073
 0.4422 0.0013 0.0011 5.0000
12.0523
0.95604
HCC1419 Cabozantinib
VEGFR2/MET
RTK
10.7779
 0.6224 -0.0111 -0.0016 5.0000
12.9768
0.90031
BT-549 Cabozantinib
VEGFR2/MET
RTK
10.1855
 0.5329 0.0124 0.0096 5.0000
12.5665
0.95054
MDA-MB-134-VI Cabozantinib
VEGFR2/MET
RTK
10.9194
 0.6362 -0.0167 -0.0063 5.0000
12.725
0.88168
MCF 10A Cabozantinib
VEGFR2/MET
RTK
25.9104
 0.8434 -0.0114 0.0040 4.9998
11.7694
0.81226
BT-20 Cediranib
VEGFR/cKIT
RTK
5.6982
 0.2210 0.0383 0.0150 2.7852
5.3221
0.97585
HCC1428 Cediranib
VEGFR/cKIT
RTK
3.1657
 -0.5502 0.1943 0.0619 1.9637
5.5392
0.98192
HCC1806 Cediranib
VEGFR/cKIT
RTK
4.9315
 0.0954 0.0645 0.0363 4.9998
4.7786
0.98723
SUM149PT Cediranib
VEGFR/cKIT
RTK
5.5644
 0.0656 0.0552 0.0262 2.8599
6.1559
0.99049
HCC38 Cediranib
VEGFR/cKIT
RTK
1.5907
 -0.2044 0.2096 0.0416 1.0695
3.1564
0.98723
HME1 Cediranib
VEGFR/cKIT
RTK
7.6446
 0.0275 0.0214 0.0244 4.8856
8.7954
0.98095
HCC1143 Cediranib
VEGFR/cKIT
RTK
3.7314
 0.0093 0.1653 0.0292 1.0590
10.5294
0.98332
MDA-MB-157 Cediranib
VEGFR/cKIT
RTK
0.82468
 -0.5845 0.3490 0.0876 0.8086
3.2088
0.96454
MDA-MB-468 Cediranib
VEGFR/cKIT
RTK
3.9154
 -0.7083 0.1649 0.0970 3.0423
5.6183
0.9962
HCC1954 Cediranib
VEGFR/cKIT
RTK
4.092
 -0.3202 0.0756 0.0534 4.9589
4.5507
0.99308
MCF 10A Cediranib
VEGFR/cKIT
RTK
9.6397
 0.4781 0.0310 0.0012 3.3546
8.1
0.99825
Hs 578T Cediranib
VEGFR/cKIT
RTK
0.55083
 -0.5723 0.3937 0.1358 0.6641
2.8803
0.96002
CAMA-1 Cediranib
VEGFR/cKIT
RTK
5.0236
 -0.2923 0.1089 0.0448 2.4671
7.8416
0.99299
SK-BR-3 Cediranib
VEGFR/cKIT
RTK
6.1955
 -0.5397 0.0755 0.0528 4.8242
7.7773
0.99548
BT-549 Cediranib
VEGFR/cKIT
RTK
3.6412
 -0.1347 0.1497 0.0414 1.3011
8.4712
0.98092
PDX1328 Cediranib
VEGFR/cKIT
RTK
0.95412
 -0.8534 0.3764 0.0972 1.1127
2.5609
0.95134
PDXHCI002 Cediranib
VEGFR/cKIT
RTK
1.4694
 -0.4324 0.2592 0.0666 0.9820
4.4977
0.98683
HCC1395 Cediranib
VEGFR/cKIT
RTK
1.571
 -0.4825 0.2460 0.0671 1.0270
4.579
0.97022
HCC70 Cediranib
VEGFR/cKIT
RTK
4.5386
 -0.3262 0.0890 0.0440 2.2440
7.4053
0.99062
MDA-MB-231 Cediranib
VEGFR/cKIT
RTK
5.0964
 -0.3620 0.1160 0.0659 2.7537
7.595
0.99835