Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-436 Cediranib
VEGFR/cKIT
RTK
3.6098
 -0.3824 0.1610 0.0446 1.8229
6.595
0.98039
HCC1954 Ceritinib
ALK
RTK
2.3105
 -0.4446 0.1668 0.0701 2.4217
3.1138
0.99363
HCC1954 Neratinib
EGFR/HER2
RTK
0.067164
 -0.0909 0.4293 0.1185 0.6344
0.096489
0.97441
HCC1954 Tivantinib
MET
RTK
0.16715
 -0.3846 0.5511 0.2533 1.4818
0.24265
0.99675
HCC1954 Cediranib
VEGFR/cKIT
RTK
4.092
 -0.3202 0.0756 0.0534 4.9589
4.5507
0.99308
HCC1954 Cabozantinib
VEGFR2/MET
RTK
10.9106
 0.6390 -0.0135 -0.0074 5.0000
13.0234
0.87916
MDA-MB-436 Tivantinib
MET
RTK
0.3675
 -0.2711 0.4215 0.0897 2.2220
0.44342
0.99833
MCF7 Cabozantinib
VEGFR2/MET
RTK
4.8819
 -0.0993 0.1069 0.0302 1.8080
8.9638
0.99698
MCF7 Cediranib
VEGFR/cKIT
RTK
5.7041
 0.1149 0.0758 0.0191 1.5383
11.6508
0.98993
MCF7 Tivantinib
MET
RTK
0.1513
 -0.0512 0.4534 0.0984 1.7693
0.15446
0.99667
MCF7 Neratinib
EGFR/HER2
RTK
1.2629
 0.0582 0.1421 0.0220 1.0034
3.7746
0.97694
MCF7 Ceritinib
ALK
RTK
0.34376
 -0.6157 0.4566 0.1487 0.9502
0.88109
0.9932
MDA-MB-436 Neratinib
EGFR/HER2
RTK
0.71562
 0.0162 0.1879 0.0162 0.8626
1.6615
0.98931
MDA-MB-436 Ceritinib
ALK
RTK
0.49893
 -0.6974 0.4169 0.1006 0.9667
1.4927
0.99602
HCC38 Cabozantinib
VEGFR2/MET
RTK
8.2108
 0.3009 0.0376 0.0168 4.3352
8.1748
0.98657
HCC38 Cediranib
VEGFR/cKIT
RTK
1.5907
 -0.2044 0.2096 0.0416 1.0695
3.1564
0.98723
HCC38 Tivantinib
MET
RTK
0.30919
 -0.2702 0.4367 0.1297 1.8013
0.39141
0.99767
HCC38 Neratinib
EGFR/HER2
RTK
3.1556
 0.4571 0.1019 0.0168 0.7043
15.0154
0.87632
HCC38 Ceritinib
ALK
RTK
1.8283
 -0.4039 0.2184 0.0883 2.6153
2.323
0.99573
MDA-MB-361 Tivantinib
MET
RTK
0.34234
 -0.6060 0.5161 0.1344 1.7286
0.54407
0.99764
HCC1428 Ceritinib
ALK
RTK
1.2414
 -0.8673 0.3014 0.1288 1.6178
2.4481
0.99584
HCC1428 Neratinib
EGFR/HER2
RTK
1.4327
 -0.0412 0.1042 0.0283 1.5482
2.7752
0.9933
PDXHCI002 Ceritinib
ALK
RTK
0.33749
 -0.6341 0.5101 0.1873 1.5133
0.59866
0.99609
PDXHCI002 Neratinib
EGFR/HER2
RTK
0.16177
 -0.1614 0.3672 0.0401 0.5156
0.9064
0.97354
PDXHCI002 Tivantinib
MET
RTK
0.23837
 -0.4868 0.5347 0.2564 2.4382
0.31389
0.99794