Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1258 Ipatasertib
AKT
PI3K/mTOR
4.4024
 0.3985 0.1556 0.0120 0.7553
1.2185
0.94717
SUM1315MO2 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.4018 0.4539 0.0330 0.0000
Inf
0.42807
HCC1395 Everolimus
mTOR1
PI3K/mTOR
0.0025601
 0.4042 0.5551 0.0370 0.4448
5.3346e-05
0.76727
MDA-MB-157 Trametinib
MEK
MAPK/nRTK
0.11147
 0.4063 0.3010 0.0221 0.6435
0.009777
0.98841
MDA-MB-468 Trametinib
MEK
MAPK/nRTK
0.4421
 0.4075 0.2132 0.0255 0.4592
0.27448
0.99227
CAL-120 Trametinib
MEK
MAPK/nRTK
0.046732
 0.4153 0.2938 0.0276 1.2901
0.011053
0.98433
Hs 578T Everolimus
mTOR1
PI3K/mTOR
0.0056053
 0.4204 0.5273 0.0278 0.4084
2.87e-05
0.64462
MDA-MB-468 Cabozantinib
VEGFR2/MET
RTK
8.9681
 0.4233 0.0441 0.0115 1.7711
16.6732
0.9812
HCC38 Olaparib
PARP
Misc
8.4247
 0.4254 0.0719 0.0230 1.0282
24.5229
0.97772
HCC1419 Trametinib
MEK
MAPK/nRTK
0.031029
 0.4259 0.2875 -0.0031 1.4893
0.0089457
0.98063
MDA-MB-231 Bleomycin
Radiation
Misc
6.333
 0.4365 0.1320 0.0030 1.0810
2.968
0.97684
HCC1419 Palbociclib
CDK4/6
Cell cycle
0.48725
 0.4414 0.2239 -0.0054 1.2398
0.053717
0.97241
SK-BR-3 Cabozantinib
VEGFR2/MET
RTK
9.7073
 0.4422 0.0013 0.0011 5.0000
12.0523
0.95604
Hs 578T Ipatasertib
AKT
PI3K/mTOR
4.5924
 0.4423 0.2458 0.0093 0.5006
0.34659
0.98155
Hs 578T Olaparib
PARP
Misc
8.9082
 0.4435 0.0997 0.0101 1.0369
25.6993
0.93656
CAMA-1 Neratinib
EGFR/HER2
RTK
2.8315
 0.4493 0.0703 0.0063 1.1466
7.3732
0.99027
HCC1395 Trametinib
MEK
MAPK/nRTK
0.17156
 0.4498 0.1903 0.0218 1.7439
0.023111
0.97973
MCF 10A Palbociclib
CDK4/6
Cell cycle
1.9503
 0.4544 0.1883 -0.0047 0.6492
0.23713
0.99244
HME1 PF-4708671
p70S6K
PI3K/mTOR
5.3765
 0.4546 0.1358 0.0746 1.1002
0.7834
0.96742
HCC1143 Olaparib
PARP
Misc
8.8262
 0.4562 0.0925 0.0158 0.7545
37.8573
0.98047
HCC38 Neratinib
EGFR/HER2
RTK
3.1556
 0.4571 0.1019 0.0168 0.7043
15.0154
0.87632
HCC1395 TGX221
PI3Kb
PI3K/mTOR
8.4625
 0.4581 0.0950 0.0125 0.6815
16.0341
0.94431
HME1 Saracatinib
SRC
MAPK/nRTK
7.2253
 0.4596 0.0026 0.0041 5.0000
4.583
0.94329
MDA-MB-453 Cabozantinib
VEGFR2/MET
RTK
9.0899
 0.4645 -0.0045 0.0208 4.5355
6.5788
0.94161
CAL-85-1 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.4714 0.1662 -0.0047 1.3900
0.27338
0.96561