Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
BT-549 Cediranib
VEGFR/cKIT
RTK
3.6412
 -0.1347 0.1497 0.0414 1.3011
8.4712
0.98092
PDXHCI002 Doxorubicin
Chemo
Chemotherapy
0.0040539
 -0.6545 0.9685 0.2951 0.9297
0.0087544
0.98094
HME1 Cediranib
VEGFR/cKIT
RTK
7.6446
 0.0275 0.0214 0.0244 4.8856
8.7954
0.98095
HCC1954 Bleomycin
Radiation
Misc
0.043847
 -0.0884 0.6166 0.2476 0.7506
0.05535
0.98102
SUM159PT Dasatinib
BCR/ABL
MAPK/nRTK
Inf
 0.5642 0.1850 0.0047 1.3689
0.14044
0.98104
SK-BR-3 Alpelisib
PI3Ka
PI3K/mTOR
0.48468
 -0.1428 0.3788 0.0660 0.4911
2.8836
0.98115
MDA-MB-453 Neratinib
EGFR/HER2
RTK
0.036055
 -0.3216 0.5532 0.1255 0.4562
0.2347
0.98118
MDA-MB-468 Cabozantinib
VEGFR2/MET
RTK
8.9681
 0.4233 0.0441 0.0115 1.7711
16.6732
0.9812
T47D Bleomycin
Radiation
Misc
0.19877
 -0.0840 0.4615 0.0190 0.9701
0.24632
0.9812
T47D Cisplatin
Chemo
Chemotherapy
1.5698
 0.1019 0.2147 0.0055 1.3290
1.5705
0.98121
HCC1954 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0096629
 -0.3280 0.5536 0.1704 0.7380
0.018218
0.98125
MDA-MB-453 Doxorubicin
Chemo
Chemotherapy
0.0058313
 -0.3476 0.7915 0.1805 1.7510
0.0071438
0.98132
T47D PF-4708671
p70S6K
PI3K/mTOR
3.7629
 0.3659 0.1275 0.0024 1.0704
1.8083
0.98136
Hs 578T Ipatasertib
AKT
PI3K/mTOR
4.5924
 0.4423 0.2458 0.0093 0.5006
0.34659
0.98155
HCC1428 ABT-737
Bcl2/XL
Misc
4.0616
 0.2431 0.1194 0.0716 1.0222
5.0858
0.98165
Hs 578T Ceritinib
ALK
RTK
0.96543
 -0.4356 0.3052 0.1254 0.8330
3.6097
0.98175
MDA-MB-468 Olaparib
PARP
Misc
7.9202
 0.3408 0.0576 0.0179 1.6505
15.4105
0.98176
HCC1428 Cediranib
VEGFR/cKIT
RTK
3.1657
 -0.5502 0.1943 0.0619 1.9637
5.5392
0.98192
Hs 578T Palbociclib
CDK4/6
Cell cycle
0.15611
 0.3049 0.3195 0.0363 0.7223
0.037735
0.98196
SUM149PT Taselisib
PI3Ka, g, d
PI3K/mTOR
2.4708
 -0.2343 0.2099 0.0774 1.0520
7.0204
0.98198
SK-BR-3 Topotecan
Topo I
Chemotherapy
0.016549
 -0.2711 0.7941 0.1919 1.9350
0.01923
0.98214
BT-20 Ipatasertib
AKT
PI3K/mTOR
0.64483
 0.1015 0.3111 0.0476 0.7459
0.59909
0.98219
HCC1419 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0091784
 -0.4046 0.8523 0.0945 0.5809
0.022714
0.98223
BT-549 Doxorubicin
Chemo
Chemotherapy
0.006482
 -0.3312 0.7603 0.1972 1.5744
0.0079126
0.9824
MDA-MB-436 Olaparib
PARP
Misc
1.536
 0.2383 0.3050 0.0296 0.3132
51.2767
0.98251