Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAL-85-1 Taxol
Chemo
Chemotherapy
0.0027273
 -0.3464 0.7931 0.3351 2.0210
0.0033785
0.95638
BT-549 Alpelisib
PI3Ka
PI3K/mTOR
17.5141
 0.6841 0.0322 0.0099 1.0429
49.8384
0.95639
MCF7 Topotecan
Topo I
Chemotherapy
0.0060429
 -0.2711 0.8540 0.1220 1.1751
0.0071167
0.95657
PDX1328 Alpelisib
PI3Ka
PI3K/mTOR
0.31193
 -0.0050 0.3735 0.0319 0.8438
0.32361
0.95669
SUM159PT A-1210477
Mcl-1
Misc
15.1726
 0.7796 0.0000 0.0026 4.9964
11.2086
0.95671
HCC1500 Etoposide
Topo II
Chemotherapy
1.4287
 -0.0766 0.2499 -0.0148 1.3319
1.7871
0.95725
HCC1419 ABT-737
Bcl2/XL
Misc
9.84
 0.4715 0.0022 0.0163 5.0000
11.4973
0.95757
Hs 578T Abemaciclib
CDK4/6
Cell cycle
0.077629
 -0.5825 0.6343 0.1966 0.4160
1.0889
0.95772
SUM149PT PF-4708671
p70S6K
PI3K/mTOR
20.5582
 0.7287 0.0241 0.0090 1.0700
53.3219
0.95776
PDX1328 Bleomycin
Radiation
Misc
4.0022
 0.3061 0.1994 0.0033 0.4524
45.3783
0.95786
MDA-MB-134-VI Topotecan
Topo I
Chemotherapy
0.0099907
 -0.8909 1.0405 0.1644 0.5440
0.071904
0.95834
HCC1937 Doxorubicin
Chemo
Chemotherapy
0.012819
 -0.1660 0.5790 0.1786 1.3570
0.012547
0.9584
HCC1419 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.5051 0.1071 0.0007 1.4251
0.82031
0.95841
T47D Olaparib
PARP
Misc
Inf
 0.5304 0.0302 0.0015 4.9632
3.5388
0.95841
HCC1937 A-1210477
Mcl-1
Misc
Inf
 0.7240 0.0060 0.0046 4.0529
5.9209
0.95858
CAL-120 Taselisib
PI3Ka, g, d
PI3K/mTOR
2.5327
 0.1514 0.2349 0.0129 0.4887
23.9822
0.95866
MDA-MB-231 Cabozantinib
VEGFR2/MET
RTK
4.8325
 0.0749 0.1413 0.0336 1.2384
11.7338
0.95871
PDX1328 Cabozantinib
VEGFR2/MET
RTK
1.8826
 -0.1622 0.2366 0.0206 0.7816
7.6768
0.95877
MCF7 AZD7762
CHK1/2
Cell cycle
0.04144
 -0.1856 0.5977 0.1318 0.8993
0.048851
0.95892
HCC1806 Neratinib
EGFR/HER2
RTK
0.77903
 -0.0883 0.1927 0.0757 0.8116
3.0161
0.95894
HCC1937 Cabozantinib
VEGFR2/MET
RTK
14.4371
 0.7602 0.0053 0.0067 4.9892
11.0339
0.95897
T47D Abemaciclib
CDK4/6
Cell cycle
0.0042816
 -0.0412 0.7664 0.0265 1.3858
0.0037683
0.95899
MDA-MB-231 Doxorubicin
Chemo
Chemotherapy
0.0050428
 -0.4864 0.8179 0.2092 1.0560
0.0077676
0.95921
HCC1428 Doxorubicin
Chemo
Chemotherapy
0.0047408
 -0.7396 0.8955 0.2242 0.5182
0.029971
0.95944
Hs 578T AZD7762
CHK1/2
Cell cycle
0.015096
 -0.5983 0.8646 0.4133 1.8783
0.01967
0.95944