Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9906 | -0.0088 | -0.0001 | 0.0000 | Inf | -0.54094 |
| SK-BR-3 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7496 | -0.0084 | 0.0076 | 4.9846 | 4.3561 | 0.86723 |
| MDA-MB-361 | A-1210477 | Mcl-1 | Misc | Inf | 0.9850 | -0.0083 | 0.0037 | 0.0000 | Inf | -0.045307 |
| HCC1806 | A-1210477 | Mcl-1 | Misc | Inf | 0.9047 | -0.0078 | 0.0015 | 4.2962 | 12.7646 | 0.58471 |
| BT-549 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.7437 | -0.0070 | 0.0034 | 2.5979 | 8.243 | 0.85998 |
| MCF7 | TGX221 | PI3Kb | PI3K/mTOR | 15.3151 | 0.7893 | -0.0068 | 0.0019 | 3.9246 | 12.6094 | 0.85557 |
| MDA-MB-361 | ABT-737 | Bcl2/XL | Misc | Inf | 0.8441 | -0.0067 | 0.0094 | 2.5452 | 4.5021 | 0.68512 |
| T47D | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7986 | -0.0066 | -0.0002 | 2.2233 | 4.3807 | 0.7868 |
| Hs 578T | A-1210477 | Mcl-1 | Misc | Inf | 0.9419 | -0.0065 | -0.0001 | 0.0000 | Inf | 0.41975 |
| HCC1419 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7941 | -0.0049 | 0.0002 | 5.0000 | 3.889 | 0.79312 |
| MDA-MB-453 | Cabozantinib | VEGFR2/MET | RTK | 9.0899 | 0.4645 | -0.0045 | 0.0208 | 4.5355 | 6.5788 | 0.94161 |
| PDX1258 | A-1210477 | Mcl-1 | Misc | Inf | 0.9187 | -0.0034 | 0.0025 | 2.4151 | 15.1662 | 0.71902 |
| HCC1806 | Cabozantinib | VEGFR2/MET | RTK | 11.367 | 0.6905 | -0.0025 | 0.0050 | 4.9955 | 13.3217 | 0.89668 |
| HCC1428 | PF-4708671 | p70S6K | PI3K/mTOR | 69.2764 | 0.8643 | -0.0019 | -0.0001 | 0.8694 | 128.134 | 0.60897 |
| MCF7 | A-1210477 | Mcl-1 | Misc | Inf | 0.8774 | -0.0002 | 0.0007 | 1.8795 | 11.2338 | 0.74456 |
| HCC1395 | ABT-737 | Bcl2/XL | Misc | Inf | 0.8607 | -0.0001 | 0.0132 | 4.9721 | 4.7028 | 0.58916 |
| SUM159PT | A-1210477 | Mcl-1 | Misc | 15.1726 | 0.7796 | 0.0000 | 0.0026 | 4.9964 | 11.2086 | 0.95671 |
| MDA-MB-157 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8240 | 0.0006 | 0.0043 | 1.2013 | 6.2128 | 0.76213 |
| CAMA-1 | ABT-737 | Bcl2/XL | Misc | Inf | 0.8643 | 0.0008 | 0.0221 | 5.0000 | 3.6752 | 0.74188 |
| HCC1395 | A-1210477 | Mcl-1 | Misc | 14.7951 | 0.8591 | 0.0009 | 0.0010 | 5.0000 | 13.8656 | 0.73508 |
| T47D | ABT-737 | Bcl2/XL | Misc | 12.2023 | 0.5888 | 0.0010 | 0.0084 | 2.2890 | 9.7541 | 0.92156 |
| SK-BR-3 | Cabozantinib | VEGFR2/MET | RTK | 9.7073 | 0.4422 | 0.0013 | 0.0011 | 5.0000 | 12.0523 | 0.95604 |
| MCF 10A | A-1210477 | Mcl-1 | Misc | Inf | 0.9527 | 0.0018 | 0.0006 | 4.5125 | 3.8181 | 0.94609 |
| MDA-MB-157 | Palbociclib | CDK4/6 | Cell cycle | Inf | 0.9754 | 0.0019 | 0.0010 | 0.0000 | Inf | 0.023059 |
| MDA-MB-436 | TGX221 | PI3Kb | PI3K/mTOR | 22.0461 | 0.7221 | 0.0019 | 0.0048 | 1.3022 | 18.6589 | 0.84405 |