Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Volasertib | PLK | Cell cycle | 0.0028671 | -0.0338 | 0.6070 | 0.1245 | 4.2176 | 0.002824 | 0.99423 |
| CAL-120 | Taxol | Chemo | Chemotherapy | 0.0028769 | -0.1987 | 0.7463 | 0.3104 | 2.6390 | 0.0032354 | 0.97877 |
| PDX1328 | Torin2 | mTOR/ATM/ATR | PI3K/mTOR | 0.0028919 | -0.3715 | 0.7187 | 0.0739 | 0.8875 | 0.004646 | 0.98005 |
| MCF7 | INK-128 | mTORC1/2 | PI3K/mTOR | 0.00298 | -0.0450 | 0.7258 | 0.1347 | 1.1028 | 0.0028216 | 0.99089 |
| PDX1328 | Taxol | Chemo | Chemotherapy | 0.002983 | -0.5332 | 0.9047 | 0.1888 | 3.1886 | 0.0036802 | 0.98401 |
| MDA-MB-361 | Taxol | Chemo | Chemotherapy | 0.0031082 | -0.6090 | 0.9738 | 0.2561 | 2.5508 | 0.0042111 | 0.9201 |
| HME1 | Taxol | Chemo | Chemotherapy | 0.0031675 | -0.2241 | 0.6794 | 0.2401 | 1.5314 | 0.0037399 | 0.98563 |
| HCC1395 | Volasertib | PLK | Cell cycle | 0.0032085 | -0.2962 | 0.7641 | 0.1714 | 2.7096 | 0.00378 | 0.99662 |
| CAMA-1 | Topotecan | Topo I | Chemotherapy | 0.0032129 | -0.4230 | 1.0539 | 0.2099 | 1.1100 | 0.0049245 | 0.96968 |
| MDA-MB-157 | Doxorubicin | Chemo | Chemotherapy | 0.0032329 | -0.7766 | 0.9661 | 0.1885 | 0.9535 | 0.006701 | 0.93404 |
| MDA-MB-453 | Luminespib | HSP90 | Misc | 0.0032643 | -0.4995 | 0.8803 | 0.2734 | 2.6468 | 0.0042685 | 0.99671 |
| CAL-85-1 | Volasertib | PLK | Cell cycle | 0.0032652 | -0.2891 | 0.7316 | 0.1652 | 2.0442 | 0.0039314 | 0.99429 |
| Hs 578T | Luminespib | HSP90 | Misc | 0.0032976 | -0.1144 | 0.6699 | 0.2289 | 2.5765 | 0.0035402 | 0.99828 |
| MDA-MB-134-VI | Doxorubicin | Chemo | Chemotherapy | 0.0033105 | -0.9458 | 1.1481 | 0.2491 | 0.9132 | 0.010163 | 0.97259 |
| MCF 10A | Trametinib | MEK | MAPK/nRTK | 0.0033619 | 0.2252 | 0.5266 | -0.0015 | 1.2096 | 0.0021432 | 0.99763 |
| MDA-MB-134-VI | INK-128 | mTORC1/2 | PI3K/mTOR | 0.0033793 | -0.8853 | 1.2003 | 0.2512 | 1.2527 | 0.007425 | 0.99747 |
| MDA-MB-453 | Taselisib | PI3Ka, g, d | PI3K/mTOR | 0.0034639 | -0.6347 | 1.0079 | 0.2403 | 0.8199 | 0.0064512 | 0.90769 |
| HCC1500 | Dasatinib | BCR/ABL | MAPK/nRTK | 0.0034818 | -0.1594 | 0.9249 | 0.0829 | 0.7537 | 0.0052374 | 0.99634 |
| T47D | Taxol | Chemo | Chemotherapy | 0.0035285 | -0.1337 | 0.6636 | 0.2505 | 2.2353 | 0.0038792 | 0.99665 |
| MDA-MB-361 | Volasertib | PLK | Cell cycle | 0.0035439 | -0.4972 | 0.8204 | 0.1921 | 4.6311 | 0.0040451 | 0.98886 |
| SK-BR-3 | Torin2 | mTOR/ATM/ATR | PI3K/mTOR | 0.0036122 | -0.3416 | 0.7338 | 0.1751 | 1.3620 | 0.0050857 | 0.99744 |
| MDA-MB-361 | INK-128 | mTORC1/2 | PI3K/mTOR | 0.0036192 | -0.8457 | 1.0956 | 0.2779 | 1.1991 | 0.0074773 | 0.98876 |
| PDX1328 | Abemaciclib | CDK4/6 | Cell cycle | 0.0036552 | -0.7514 | 0.8680 | 0.0940 | 0.2489 | 0.30192 | 0.79917 |
| PDXHCI002 | Volasertib | PLK | Cell cycle | 0.0037003 | -0.5892 | 0.8480 | 0.3925 | 4.6276 | 0.0042869 | 0.99531 |
| MDA-MB-436 | Taxol | Chemo | Chemotherapy | 0.0037097 | -0.2183 | 0.7083 | 0.1530 | 3.2043 | 0.0040962 | 0.99739 |