Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAMA-1 Etoposide
Topo II
Chemotherapy
0.15466
 -0.4476 0.5722 0.1479 1.3512
0.24426
0.99498
BT-549 Dinaciclib
pan CDK
Cell cycle
0.012371
 -0.2923 0.5913 0.1485 3.7837
0.013904
0.99899
MCF7 Ceritinib
ALK
RTK
0.34376
 -0.6157 0.4566 0.1487 0.9502
0.88109
0.9932
MDA-MB-134-VI AZD7762
CHK1/2
Cell cycle
0.10625
 -0.6459 0.6552 0.1488 1.1125
0.22232
0.99438
BT-549 Volasertib
PLK
Cell cycle
0.0088352
 -0.2289 0.5676 0.1490 2.4967
0.0098732
0.99586
MCF 10A Tivantinib
MET
RTK
0.18116
 -0.1502 0.4509 0.1498 2.3782
0.1918
0.99221
BT-549 Bleomycin
Radiation
Misc
0.17998
 -0.0141 0.4667 0.1506 1.0031
0.20287
0.99525
PDX1328 Topotecan
Topo I
Chemotherapy
0.0059222
 -0.9128 1.0720 0.1509 0.4616
0.063175
0.94441
MDA-MB-468 Neratinib
EGFR/HER2
RTK
0.15781
 -0.3825 0.3861 0.1513 0.8303
0.41607
0.99579
HCC70 Tivantinib
MET
RTK
0.3335
 -0.5657 0.4968 0.1515 2.0000
0.48673
0.99617
Hs 578T Buparlisib
pan PI3K
PI3K/mTOR
0.68631
 -0.3434 0.3760 0.1520 1.4596
1.0562
0.9918
MDA-MB-134-VI Dinaciclib
pan CDK
Cell cycle
0.010529
 -0.8440 0.7452 0.1522 2.1701
0.015963
0.99365
PDXHCI002 Luminespib
HSP90
Misc
0.0043954
 -0.2805 0.7099 0.1525 3.6850
0.0049332
0.9976
MDA-MB-453 Abemaciclib
CDK4/6
Cell cycle
0.0057723
 -0.7647 0.8495 0.1526 0.2725
0.32512
0.73985
MDA-MB-436 Taxol
Chemo
Chemotherapy
0.0037097
 -0.2183 0.7083 0.1530 3.2043
0.0040962
0.99739
SK-BR-3 Vorinostat
HDAC
Misc
0.7625
 -0.6322 0.3637 0.1534 2.3291
1.0657
0.99404
SUM149PT Cisplatin
Chemo
Chemotherapy
0.57047
 -0.2290 0.3547 0.1535 0.9378
0.98129
0.99267
PDX1328 ABT-737
Bcl2/XL
Misc
1.0279
 -0.8967 0.3548 0.1542 1.3255
2.3546
0.97784
HCC1395 Doxorubicin
Chemo
Chemotherapy
0.01793
 -0.4166 0.6370 0.1543 1.1158
0.025315
0.96347
HCC70 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.15092
 -0.6846 0.5796 0.1546 0.7043
0.64661
0.98584
HCC1395 Dinaciclib
pan CDK
Cell cycle
0.012405
 -0.4966 0.6520 0.1554 2.9854
0.015612
0.99791
MDA-MB-468 Luminespib
HSP90
Misc
0.0048347
 -0.1738 0.6478 0.1563 4.7025
0.0051177
0.99878
CAL-120 Tivantinib
MET
RTK
0.25132
 -0.2562 0.4649 0.1572 1.1267
0.37355
0.99876
MDA-MB-453 Ceritinib
ALK
RTK
0.36617
 -0.6866 0.4840 0.1577 1.1705
0.84209
0.99139
HCC1419 Luminespib
HSP90
Misc
0.0069643
 -0.2968 0.6506 0.1579 2.0439
0.0087353
0.99699