Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SK-BR-3 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.7496 -0.0084 0.0076 4.9846
4.3561
0.86723
HCC1954 A-1210477
Mcl-1
Misc
Inf
 0.8844 -0.0259 0.0076 0.0000
Inf
0.43063
HCC1428 Saracatinib
SRC
MAPK/nRTK
Inf
 0.6691 0.0697 0.0076 0.8735
1.6565
0.94133
SUM149PT Alpelisib
PI3Ka
PI3K/mTOR
Inf
 0.8446 0.0387 0.0076 0.5903
8.2866
0.80431
T47D Palbociclib
CDK4/6
Cell cycle
0.027507
 0.1166 0.4501 0.0077 1.5536
0.022367
0.99262
HME1 Pictilisib
pan PI3K
PI3K/mTOR
2.8093
 0.1260 0.1418 0.0078 1.0287
3.8551
0.98326
CAL-120 Saracatinib
SRC
MAPK/nRTK
15.6396
 0.5261 0.1730 0.0078 0.3429
33.0327
0.96689
HME1 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.6353 0.0365 0.0079 1.2722
3.6876
0.93611
HME1 Alpelisib
PI3Ka
PI3K/mTOR
6.0356
 0.3071 0.1123 0.0079 0.9018
20.4027
0.98253
HCC1500 A-1210477
Mcl-1
Misc
Inf
 0.8719 -0.0368 0.0081 0.0000
Inf
0.32761
T47D ABT-737
Bcl2/XL
Misc
12.2023
 0.5888 0.0010 0.0084 2.2890
9.7541
0.92156
HCC1500 Olaparib
PARP
Misc
6.3506
 0.2744 0.0985 0.0084 1.0887
17.4212
0.94589
MDA-MB-231 Cisplatin
Chemo
Chemotherapy
2.415
 0.2721 0.1500 0.0084 1.6944
1.6486
0.99899
SUM159PT Cediranib
VEGFR/cKIT
RTK
8.1187
 0.3173 0.0491 0.0085 2.1882
12.8042
0.99762
HCC1937 Alpelisib
PI3Ka
PI3K/mTOR
18.8171
 0.6577 0.0501 0.0085 0.8078
73.2808
0.94623
HCC1806 Palbociclib
CDK4/6
Cell cycle
Inf
 0.6924 0.1460 0.0085 1.6543
0.024125
0.93749
HCC1419 Cisplatin
Chemo
Chemotherapy
1.7988
 0.0949 0.2293 0.0086 1.0769
2.0814
0.93793
T47D Dasatinib
BCR/ABL
MAPK/nRTK
12.5697
 0.4961 0.1933 0.0086 0.2753
679.7315
0.95229
BT-20 Olaparib
PARP
Misc
15.2735
 0.6064 0.0657 0.0087 0.8235
57.982
0.94742
T47D Saracatinib
SRC
MAPK/nRTK
3.9647
 0.3892 0.1722 0.0087 0.6928
1.6318
0.9752
HCC1395 Alpelisib
PI3Ka
PI3K/mTOR
14.2707
 0.6375 0.0319 0.0088 1.2066
35.4714
0.90001
HCC1428 Olaparib
PARP
Misc
0.55326
 0.1185 0.3229 0.0089 0.8769
0.48774
0.98952
SUM149PT PF-4708671
p70S6K
PI3K/mTOR
20.5582
 0.7287 0.0241 0.0090 1.0700
53.3219
0.95776
CAMA-1 Cabozantinib
VEGFR2/MET
RTK
8.7107
 0.2436 0.0342 0.0090 4.9963
10.1282
0.97965
CAL-51 ABT-737
Bcl2/XL
Misc
30.4739
 0.8756 0.0125 0.0091 1.7501
30.7264
0.93007