Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SUM159PT Buparlisib
pan PI3K
PI3K/mTOR
1.5871
 -0.1942 0.2253 0.0613 1.5281
2.1811
0.99923
SUM159PT Pictilisib
pan PI3K
PI3K/mTOR
1.2625
 0.0942 0.2390 -0.0024 0.9852
1.2984
0.99746
SUM159PT Ceritinib
ALK
RTK
1.5606
 -0.3800 0.2590 0.1427 2.5153
1.9758
0.99862
SUM159PT Neratinib
EGFR/HER2
RTK
1.0155
 0.3337 0.1585 0.0028 0.9807
0.58582
0.99938
SUM159PT Tivantinib
MET
RTK
0.37997
 -0.1921 0.3954 0.1806 2.0717
0.4458
0.9982
SUM159PT Cediranib
VEGFR/cKIT
RTK
8.1187
 0.3173 0.0491 0.0085 2.1882
12.8042
0.99762
T47D Cabozantinib
VEGFR2/MET
RTK
7.8808
 0.3126 0.0578 0.0045 1.8911
14.0627
0.99417
T47D Cediranib
VEGFR/cKIT
RTK
4.1027
 -0.6403 0.1246 0.0754 2.9281
5.9706
0.99504
T47D Tivantinib
MET
RTK
0.3478
 -0.1544 0.3824 0.1267 3.7033
0.37139
0.99567
T47D Neratinib
EGFR/HER2
RTK
0.42314
 0.1949 0.2741 0.0059 0.4966
0.81232
0.9874
T47D Ceritinib
ALK
RTK
1.5629
 -0.8550 0.3123 0.1208 1.6029
3.1015
0.97809
T47D Pictilisib
pan PI3K
PI3K/mTOR
0.15529
 -0.1470 0.4772 0.0336 0.7031
0.2394
0.99267
T47D Buparlisib
pan PI3K
PI3K/mTOR
0.24826
 -0.4183 0.4821 0.0867 0.7426
0.73229
0.99516
T47D PF-4708671
p70S6K
PI3K/mTOR
3.7629
 0.3659 0.1275 0.0024 1.0704
1.8083
0.98136
T47D INK-128
mTORC1/2
PI3K/mTOR
0.0052554
 -0.0486 0.6885 0.0237 1.4713
0.0052599
0.99662
T47D Everolimus
mTOR1
PI3K/mTOR
-Inf
 0.2975 0.6157 0.0150 0.1000
5.9599e-07
0.77906
T47D Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0060179
 0.0099 0.5239 0.0218 1.4244
0.0056296
0.99382
T47D TGX221
PI3Kb
PI3K/mTOR
Inf
 0.7986 -0.0066 -0.0002 2.2233
4.3807
0.7868
T47D Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0017858
 -0.1047 0.8990 0.0550 1.1740
0.0018197
0.97255
T47D Alpelisib
PI3Ka
PI3K/mTOR
0.15284
 -0.0332 0.4568 0.0181 0.7816
0.17573
0.98947
T47D Ipatasertib
AKT
PI3K/mTOR
0.13653
 0.1331 0.4303 0.0112 1.0853
0.10541
0.99474
T47D Bleomycin
Radiation
Misc
0.19877
 -0.0840 0.4615 0.0190 0.9701
0.24632
0.9812
T47D Olaparib
PARP
Misc
Inf
 0.5304 0.0302 0.0015 4.9632
3.5388
0.95841
T47D A-1210477
Mcl-1
Misc
Inf
 0.5752 0.0227 0.0055 5.0000
3.7781
0.96287
T47D Luminespib
HSP90
Misc
0.0060689
 0.0212 0.5165 0.0278 4.3267
0.0059347
0.99479