Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC38 Etoposide
Topo II
Chemotherapy
0.33384
 -0.4242 0.4494 0.1891 1.4384
0.50554
0.99763
HCC38 Topotecan
Topo I
Chemotherapy
0.0068073
 -0.5041 1.0724 0.3904 1.2181
0.011735
0.99338
HCC38 Taxol
Chemo
Chemotherapy
0.0014659
 -0.3078 0.8432 0.2758 2.3201
0.0017274
0.99328
HCC38 Doxorubicin
Chemo
Chemotherapy
0.0095452
 -0.4061 0.7803 0.2872 1.4810
0.01343
0.99228
HCC38 Cisplatin
Chemo
Chemotherapy
0.99272
 -0.1031 0.2567 0.1098 1.4350
1.1794
0.99675
HCC38 Dinaciclib
pan CDK
Cell cycle
0.012678
 -0.4422 0.6326 0.2241 4.1199
0.014763
0.99821
HCC38 Volasertib
PLK
Cell cycle
0.0081934
 -0.2598 0.6001 0.1943 3.2088
0.0091367
0.99678
HCC38 AZD7762
CHK1/2
Cell cycle
0.0094764
 -0.3341 0.9185 0.2951 2.0434
0.01177
0.98869
HCC38 Palbociclib
CDK4/6
Cell cycle
0.059804
 0.1474 0.3722 0.0411 1.0985
0.037879
0.98636
HCC38 Abemaciclib
CDK4/6
Cell cycle
0.044561
 -0.3272 0.6404 0.0910 0.4303
0.21535
0.96385
HCC70 Cabozantinib
VEGFR2/MET
RTK
1.5024
 -0.0911 0.2658 0.0226 0.5892
9.6961
0.92355
HCC70 Cediranib
VEGFR/cKIT
RTK
4.5386
 -0.3262 0.0890 0.0440 2.2440
7.4053
0.99062
HCC70 Tivantinib
MET
RTK
0.3335
 -0.5657 0.4968 0.1515 2.0000
0.48673
0.99617
HCC70 Neratinib
EGFR/HER2
RTK
0.16013
 0.0595 0.3178 0.0405 1.0555
0.15156
0.99467
HCC70 Ceritinib
ALK
RTK
3.1923
 -0.8808 0.1379 0.0703 5.0000
3.9213
0.99483
HCC70 Pictilisib
pan PI3K
PI3K/mTOR
0.16052
 -0.5972 0.5726 0.1167 0.7256
0.58082
0.99601
HCC70 Buparlisib
pan PI3K
PI3K/mTOR
0.43342
 -0.7274 0.4614 0.1434 1.1927
1.0047
0.99537
HCC70 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.9348 -0.0227 0.0035 0.0000
Inf
0.040075
HCC70 INK-128
mTORC1/2
PI3K/mTOR
0.0048011
 -0.1620 0.7024 0.0912 1.1840
0.0050026
0.97794
HCC70 Everolimus
mTOR1
PI3K/mTOR
0.24351
 0.3727 0.4764 0.0448 0.1135
51.0339
0.79604
HCC70 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0058452
 -0.5550 0.6451 0.1234 0.5307
0.026938
0.94991
HCC70 TGX221
PI3Kb
PI3K/mTOR
0.092754
 0.0049 0.4729 0.0591 0.8818
0.076452
0.9787
HCC70 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.15092
 -0.6846 0.5796 0.1546 0.7043
0.64661
0.98584
HCC70 Alpelisib
PI3Ka
PI3K/mTOR
4.4987
 0.0981 0.1182 0.0196 1.0448
12.8744
0.95143
HCC70 Ipatasertib
AKT
PI3K/mTOR
0.1397
 -0.2624 0.4974 0.0860 0.8534
0.21677
0.98567