Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1419 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.5051 0.1071 0.0007 1.4251
0.82031
0.95841
HCC1419 Alpelisib
PI3Ka
PI3K/mTOR
0.66882
 -0.0020 0.3558 0.0157 0.3922
11.0132
0.94051
HCC1419 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0091784
 -0.4046 0.8523 0.0945 0.5809
0.022714
0.98223
HCC1419 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.1803 0.7242 0.0249 0.0000
Inf
0.37602
HCC1419 INK-128
mTORC1/2
PI3K/mTOR
0.0047477
 -0.1472 0.7635 0.0603 1.3112
0.0056144
0.99448
HCC1419 Saracatinib
SRC
MAPK/nRTK
0.91888
 -0.1146 0.2758 0.0128 0.8021
1.8388
0.98394
HCC1419 ABT-737
Bcl2/XL
Misc
9.84
 0.4715 0.0022 0.0163 5.0000
11.4973
0.95757
HCC1419 Trametinib
MEK
MAPK/nRTK
0.031029
 0.4259 0.2875 -0.0031 1.4893
0.0089457
0.98063
HCC1419 Vorinostat
HDAC
Misc
1.735
 -0.2557 0.1917 0.0407 2.1116
2.1704
0.99173
HCC1419 Topotecan
Topo I
Chemotherapy
0.0071886
 -0.7857 0.9904 0.1711 0.4002
0.11192
0.94532
HCC1419 Etoposide
Topo II
Chemotherapy
0.73579
 0.0317 0.3201 0.0034 1.8770
0.70309
0.96133
HCC1419 Dasatinib
BCR/ABL
MAPK/nRTK
0.82399
 -0.1962 0.3189 0.0194 0.7548
2.3816
0.99358
HCC1419 Luminespib
HSP90
Misc
0.0069643
 -0.2968 0.6506 0.1579 2.0439
0.0087353
0.99699
HCC1419 Dinaciclib
pan CDK
Cell cycle
0.026695
 -0.4761 0.5131 0.1238 5.0000
0.030191
0.99589
HCC1419 Cisplatin
Chemo
Chemotherapy
1.7988
 0.0949 0.2293 0.0086 1.0769
2.0814
0.93793
HCC1419 Volasertib
PLK
Cell cycle
0.020718
 0.0685 0.3636 0.0462 1.8241
0.018178
0.98538
HCC1419 Doxorubicin
Chemo
Chemotherapy
0.025082
 -0.4663 0.5904 0.0473 0.5199
0.10425
0.94593
HCC1419 Palbociclib
CDK4/6
Cell cycle
0.48725
 0.4414 0.2239 -0.0054 1.2398
0.053717
0.97241
HCC1419 Taxol
Chemo
Chemotherapy
0.0052608
 0.2143 0.4700 0.0981 2.1841
0.0040283
0.97754
HCC1419 A-1210477
Mcl-1
Misc
14.536
 0.7081 0.0402 0.0018 1.8053
26.3399
0.8672
HCC1419 AZD7762
CHK1/2
Cell cycle
0.068618
 -0.0826 0.5614 0.1156 2.0553
0.072481
0.98917
HCC1419 Cediranib
VEGFR/cKIT
RTK
5.0599
 -0.0329 0.0545 0.0124 4.9952
5.1984
0.99032
HCC1419 Cabozantinib
VEGFR2/MET
RTK
10.7779
 0.6224 -0.0111 -0.0016 5.0000
12.9768
0.90031
HCC1419 Pictilisib
pan PI3K
PI3K/mTOR
0.17196
 -0.2103 0.5118 0.0340 0.5444
0.61152
0.99425
HCC1419 Ceritinib
ALK
RTK
2.6149
 -0.8670 0.2083 0.0855 2.5745
4.0066
0.99248