Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1143 Pictilisib
pan PI3K
PI3K/mTOR
0.97831
 -0.1291 0.3201 0.0583 0.5213
8.0489
0.97859
HCC1143 Ceritinib
ALK
RTK
1.4479
 -0.4219 0.2848 0.0621 1.0347
4.1868
0.99172
HCC1143 Luminespib
HSP90
Misc
0.0039434
 -0.1922 0.7017 0.1659 3.6671
0.0042921
0.99512
HCC1143 Vorinostat
HDAC
Misc
0.91041
 -0.2533 0.2953 0.0977 1.9423
1.1249
0.99293
HCC1143 A-1210477
Mcl-1
Misc
16.3987
 0.6719 0.0640 0.0008 1.0821
44.847
0.81227
HCC1143 Saracatinib
SRC
MAPK/nRTK
3.0304
 0.3881 0.2375 0.0437 0.4638
1.6973
0.97807
HCC1143 ABT-737
Bcl2/XL
Misc
6.1992
 0.3758 0.1027 0.0110 0.8672
8.5825
0.98522
HCC1143 Olaparib
PARP
Misc
8.8262
 0.4562 0.0925 0.0158 0.7545
37.8573
0.98047
HCC1143 Dasatinib
BCR/ABL
MAPK/nRTK
0.13934
 0.2573 0.4469 0.1044 0.5121
0.046932
0.96213
HCC1143 Bleomycin
Radiation
Misc
0.04818
 -0.2085 0.6578 0.1955 1.0629
0.066427
0.9974
HCC1143 Ipatasertib
AKT
PI3K/mTOR
80.6794
 0.7509 0.0662 -0.0023 0.4354
999.9134
0.83579
HCC1143 Trametinib
MEK
MAPK/nRTK
0.0088297
 -0.0225 0.5379 0.1187 0.5756
0.013291
0.99613
HCC1143 Neratinib
EGFR/HER2
RTK
0.67229
 0.0791 0.2379 0.0489 0.5527
4.9078
0.98415
HCC1395 Tivantinib
MET
RTK
0.47525
 -0.4835 0.4006 0.1208 1.5047
0.75467
0.99624
HCC1395 Cediranib
VEGFR/cKIT
RTK
1.571
 -0.4825 0.2460 0.0671 1.0270
4.579
0.97022
HCC1395 Neratinib
EGFR/HER2
RTK
0.95453
 0.0167 0.1503 0.0198 0.8768
3.3415
0.98547
HCC1395 Cabozantinib
VEGFR2/MET
RTK
5.5518
 0.1138 0.0722 0.0131 1.6522
9.2961
0.98977
HCC1395 Doxorubicin
Chemo
Chemotherapy
0.01793
 -0.4166 0.6370 0.1543 1.1158
0.025315
0.96347
HCC1395 Taxol
Chemo
Chemotherapy
0.003883
 -0.4582 0.8386 0.2364 2.6973
0.0049059
0.99722
HCC1395 AZD7762
CHK1/2
Cell cycle
0.02128
 -0.6899 0.8845 0.2607 2.2723
0.028104
0.96763
HCC1395 Volasertib
PLK
Cell cycle
0.0032085
 -0.2962 0.7641 0.1714 2.7096
0.00378
0.99662
HCC1395 Dinaciclib
pan CDK
Cell cycle
0.012405
 -0.4966 0.6520 0.1554 2.9854
0.015612
0.99791
HCC1395 Pictilisib
pan PI3K
PI3K/mTOR
1.4354
 -0.0143 0.2288 0.0238 0.8947
2.3303
0.98423
HCC1395 Cisplatin
Chemo
Chemotherapy
0.49099
 -0.2215 0.3857 0.0943 0.9090
0.84369
0.97444
HCC1395 Topotecan
Topo I
Chemotherapy
0.0027504
 -0.5835 1.0761 0.3115 0.5889
0.0088299
0.93292