Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1500 AZD7762
CHK1/2
Cell cycle
0.035943
 -0.2559 0.6218 0.1217 1.0434
0.037616
0.91391
HCC1395 Luminespib
HSP90
Misc
0.0049953
 -0.1520 0.6195 0.0752 3.9193
0.0052747
0.99634
HCC1954 Luminespib
HSP90
Misc
0.010331
 -0.3745 0.6188 0.2958 2.6936
0.012628
0.99618
HCC1500 Taxol
Chemo
Chemotherapy
0.0038131
 -0.0589 0.6182 0.1433 1.8138
0.0038924
0.96247
HCC1954 Bleomycin
Radiation
Misc
0.043847
 -0.0884 0.6166 0.2476 0.7506
0.05535
0.98102
Hs 578T Dinaciclib
pan CDK
Cell cycle
0.0089363
 -0.2388 0.6160 0.2121 4.9934
0.0096082
0.99916
T47D Everolimus
mTOR1
PI3K/mTOR
-Inf
 0.2975 0.6157 0.0150 0.1000
5.9599e-07
0.77906
MDA-MB-157 Luminespib
HSP90
Misc
0.0041789
 -0.0490 0.6146 0.0676 4.3520
0.004258
0.99849
HCC1954 Volasertib
PLK
Cell cycle
0.0065835
 -0.1540 0.6139 0.2792 3.4968
0.0071308
0.99812
MCF 10A Luminespib
HSP90
Misc
0.0076226
 -0.1717 0.6131 0.2622 3.1403
0.0083878
0.9999
CAMA-1 Abemaciclib
CDK4/6
Cell cycle
0.007859
 0.2222 0.6130 -0.0040 1.3608
0.0046978
0.97968
BT-549 Luminespib
HSP90
Misc
0.0053858
 -0.1064 0.6123 0.1201 5.0000
0.0055748
0.99911
MDA-MB-361 Buparlisib
pan PI3K
PI3K/mTOR
0.21797
 -0.9584 0.6114 0.1763 0.9709
0.67584
0.99384
SUM1315MO2 Luminespib
HSP90
Misc
0.0048627
 -0.0810 0.6112 0.1374 5.0000
0.0050309
0.99738
PDX1258 Luminespib
HSP90
Misc
0.01007
 -0.2899 0.6101 0.1943 5.0000
0.011049
0.99799
MDA-MB-157 Etoposide
Topo II
Chemotherapy
0.11187
 -0.4340 0.6092 0.0639 1.5161
0.15792
0.98866
MCF7 Volasertib
PLK
Cell cycle
0.0028671
 -0.0338 0.6070 0.1245 4.2176
0.002824
0.99423
HCC1395 Bleomycin
Radiation
Misc
0.10419
 -0.4023 0.6070 0.1775 0.6889
0.30452
0.9971
SUM159PT Doxorubicin
Chemo
Chemotherapy
0.019121
 -0.2740 0.6068 0.2965 1.5857
0.022541
0.98806
CAMA-1 Dinaciclib
pan CDK
Cell cycle
0.014558
 -0.4849 0.6062 0.1927 2.0283
0.019954
0.99839
PDXHCI002 Dinaciclib
pan CDK
Cell cycle
0.012194
 -0.3607 0.6030 0.2029 4.6252
0.01372
0.99728
MCF7 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0045641
 -0.1330 0.6027 0.1279 0.9398
0.0052657
0.98973
CAL-120 INK-128
mTORC1/2
PI3K/mTOR
0.011487
 -0.0097 0.6018 0.0545 1.3448
0.011154
0.99759
HCC1395 Dasatinib
BCR/ABL
MAPK/nRTK
0.074545
 -0.3369 0.6018 0.0918 1.9595
0.089698
0.98974
MDA-MB-361 Dinaciclib
pan CDK
Cell cycle
0.011817
 -0.2748 0.6004 0.0836 5.0000
0.013067
0.99187