Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1258 Alpelisib
PI3Ka
PI3K/mTOR
17.8572
 0.6307 0.0589 0.0069 0.7348
79.6392
0.9089
PDX1258 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.99608
 0.1062 0.2777 0.0362 0.6747
1.3027
0.98871
PDX1258 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.9970 -0.0328 0.0026 0.0000
Inf
-2.2747
PDX1258 Buparlisib
pan PI3K
PI3K/mTOR
1.3631
 -0.3924 0.2516 0.0862 1.2064
2.8058
0.99443
PDX1258 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.035598
 -0.2066 0.3637 0.0836 1.5171
0.041875
0.98779
PDX1258 A-1210477
Mcl-1
Misc
Inf
 0.9187 -0.0034 0.0025 2.4151
15.1662
0.71902
PDX1258 Olaparib
PARP
Misc
11.9912
 0.5770 0.0287 0.0113 1.2287
29.2905
0.94883
PDX1258 Luminespib
HSP90
Misc
0.01007
 -0.2899 0.6101 0.1943 5.0000
0.011049
0.99799
PDX1258 ABT-737
Bcl2/XL
Misc
Inf
 0.7580 0.0124 0.0237 0.9162
13.677
0.78603
PDX1258 Vorinostat
HDAC
Misc
1.5746
 -0.0232 0.2113 0.0249 1.3725
1.8225
0.99287
PDX1258 Bleomycin
Radiation
Misc
0.78329
 0.0721 0.2946 0.0937 0.8662
0.88979
0.99416
PDX1258 Saracatinib
SRC
MAPK/nRTK
0.7252
 0.1837 0.2770 0.0370 0.8198
0.50742
0.98008
PDX1258 Etoposide
Topo II
Chemotherapy
0.31701
 -0.1807 0.3942 0.1360 1.0906
0.41876
0.99346
PDX1258 Dasatinib
BCR/ABL
MAPK/nRTK
0.021598
 -0.1339 0.7143 0.0924 1.3176
0.024774
0.99367
PDX1258 Topotecan
Topo I
Chemotherapy
0.013472
 -0.4565 0.8673 0.2817 0.8122
0.026852
0.98013
PDX1258 Ipatasertib
AKT
PI3K/mTOR
4.4024
 0.3985 0.1556 0.0120 0.7553
1.2185
0.94717
PDX1258 Doxorubicin
Chemo
Chemotherapy
0.0091389
 -0.4928 0.7540 0.2368 1.1844
0.013938
0.97567
PDX1258 Taxol
Chemo
Chemotherapy
0.0021522
 -0.0818 0.6797 0.2357 1.2501
0.0022935
0.98829
PDX1258 Volasertib
PLK
Cell cycle
0.0073734
 -0.2320 0.5602 0.1765 1.8198
0.0083258
0.98847
PDX1258 Cisplatin
Chemo
Chemotherapy
2.5568
 0.3181 0.1555 0.0433 1.6027
1.5449
0.99079
PDX1258 Dinaciclib
pan CDK
Cell cycle
0.011566
 -0.6173 0.7036 0.2838 3.5943
0.014366
0.99779
PDX1258 AZD7762
CHK1/2
Cell cycle
0.014946
 -0.4528 0.9199 0.3234 1.6838
0.021221
0.99249
MDA-MB-468 Neratinib
EGFR/HER2
RTK
0.15781
 -0.3825 0.3861 0.1513 0.8303
0.41607
0.99579
MDA-MB-468 Tivantinib
MET
RTK
0.30706
 -0.4549 0.4903 0.2341 2.9835
0.37002
0.99499
MDA-MB-468 Cabozantinib
VEGFR2/MET
RTK
8.9681
 0.4233 0.0441 0.0115 1.7711
16.6732
0.9812