Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| MDA-MB-134-VI | Alpelisib | 0.31623 | PI3Ka | PI3K/mTOR | 2.6051 | 0.00077 |
| MDA-MB-134-VI | Saracatinib | 1.0 | SRC | MAPK/nRTK | 2.5167 | 0.01029 |
| MDA-MB-134-VI | Saracatinib | 3.1623 | SRC | MAPK/nRTK | 2.4237 | 0.00199 |
| MDA-MB-134-VI | Saracatinib | 0.31623 | SRC | MAPK/nRTK | 1.9344 | 0.02326 |
| MDA-MB-134-VI | Saracatinib | 0.1 | SRC | MAPK/nRTK | 1.8592 | 0.03218 |
| MDA-MB-134-VI | Saracatinib | 0.01 | SRC | MAPK/nRTK | 1.8309 | 0.02283 |
| MDA-MB-134-VI | Dasatinib | 0.31623 | BCR/ABL | MAPK/nRTK | 1.7076 | -0.00320 |
| MDA-MB-134-VI | Dasatinib | 1.0 | BCR/ABL | MAPK/nRTK | 1.5703 | -0.00324 |
| MDA-MB-134-VI | PF-4708671 | 0.0031623 | p70S6K | PI3K/mTOR | 1.5306 | -0.00002 |
| MDA-MB-134-VI | Saracatinib | 0.031623 | SRC | MAPK/nRTK | 1.4699 | 0.02402 |
| MDA-MB-134-VI | AZD7762 | 0.01 | CHK1/2 | Cell cycle | 1.4630 | 0.02565 |
| MDA-MB-134-VI | Luminespib | 0.001 | HSP90 | Misc | 1.4508 | -0.01106 |
| MDA-MB-134-VI | Saracatinib | 0.0031623 | SRC | MAPK/nRTK | 1.4491 | 0.00939 |
| PDXHCI002 | Torin2 | 0.01 | mTOR/ATM/ATR | PI3K/mTOR | 1.4354 | -0.04922 |
| HCC70 | Ceritinib | 0.001 | ALK | RTK | 1.4221 | 0.00355 |
| MDA-MB-134-VI | AZD7762 | 0.001 | CHK1/2 | Cell cycle | 1.4161 | -0.00132 |
| MDA-MB-134-VI | Neratinib | 0.01 | EGFR/HER2 | RTK | 1.4151 | -0.01219 |
| MDA-MB-134-VI | Volasertib | 0.00031623 | PLK | Cell cycle | 1.4141 | 0.00230 |
| PDXHCI002 | INK-128 | 0.0031623 | mTORC1/2 | PI3K/mTOR | 1.4120 | -0.03534 |
| PDX1328 | AZD7762 | 0.0031623 | CHK1/2 | Cell cycle | 1.4111 | 0.00161 |
| HCC1428 | Cisplatin | 0.01 | Chemo | Chemotherapy | 1.4076 | -0.00053 |
| MDA-MB-134-VI | Saracatinib | 10.0 | SRC | MAPK/nRTK | 1.4045 | 0.03093 |
| MDA-MB-134-VI | Vorinostat | 0.031623 | HDAC | Misc | 1.4016 | 0.00246 |
| MDA-MB-134-VI | Vorinostat | 0.1 | HDAC | Misc | 1.3902 | 0.00733 |
| MDA-MB-134-VI | Dasatinib | 0.01 | BCR/ABL | MAPK/nRTK | 1.3853 | 0.00770 |