Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF 10A Trametinib
0.0001
MEK
MAPK/nRTK
 0.9875 -0.00048
MCF7 Luminespib
0.0001
HSP90
Misc
 1.0129 -0.00003
Hs 578T Volasertib
0.0001
PLK
Cell cycle
 0.9564 -0.00165
MCF 10A Taxol
0.0001
Chemo
Chemotherapy
 0.9571 0.00191
MCF7 Volasertib
0.0001
PLK
Cell cycle
 1.0847 -0.00321
MCF7 Trametinib
0.0001
MEK
MAPK/nRTK
 1.0030 -0.00089
HCC1806 Luminespib
0.0001
HSP90
Misc
 1.0518 -0.00289
HCC1806 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0343 -0.00199
Hs 578T Luminespib
0.0001
HSP90
Misc
 0.9779 0.00503
MCF 10A Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0083 0.00069
MCF 10A Luminespib
0.0001
HSP90
Misc
 0.9989 0.00064
MCF 10A Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0023 -0.00057
MCF7 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0167 -0.00027
MCF7 Taxol
0.0001
Chemo
Chemotherapy
 0.7154 0.02464
HCC1806 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0433 -0.00285
HCC1806 Trametinib
0.0001
MEK
MAPK/nRTK
 1.0301 0.00613
HCC1806 Volasertib
0.0001
PLK
Cell cycle
 1.0118 0.00039
HCC1806 Taxol
0.0001
Chemo
Chemotherapy
 0.7362 0.03761
Hs 578T Taxol
0.0001
Chemo
Chemotherapy
 0.6739 0.08314
Hs 578T Trametinib
0.0001
MEK
MAPK/nRTK
 0.9824 -0.00001
Hs 578T Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0888 0.00475
MCF 10A Volasertib
0.0001
PLK
Cell cycle
 1.0023 0.00027
Hs 578T Dinaciclib
0.0001
pan CDK
Cell cycle
 0.9649 0.00169
MDA-MB-231 Volasertib
0.0001
PLK
Cell cycle
 1.0247 0.00180
MCF7 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 0.9564 0.00563
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