Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
BT-549 Abemaciclib
10.0
CDK4/6
Cell cycle
 0.0333 0.15095
BT-549 Palbociclib
0.00031623
CDK4/6
Cell cycle
 1.0163 0.00360
BT-549 Palbociclib
0.001
CDK4/6
Cell cycle
 1.0331 0.00886
BT-549 Palbociclib
0.0031623
CDK4/6
Cell cycle
 1.0202 -0.00027
BT-549 Palbociclib
0.01
CDK4/6
Cell cycle
 1.0649 0.00372
BT-549 Palbociclib
0.031623
CDK4/6
Cell cycle
 1.0582 -0.00203
BT-549 Palbociclib
0.1
CDK4/6
Cell cycle
 1.0491 0.00209
BT-549 Palbociclib
0.31623
CDK4/6
Cell cycle
 1.0356 -0.00357
BT-549 Palbociclib
1.0
CDK4/6
Cell cycle
 1.0826 -0.00648
BT-549 Palbociclib
3.1623
CDK4/6
Cell cycle
 1.0889 -0.01545
BT-549 AZD7762
0.001
CHK1/2
Cell cycle
 1.1190 -0.00579
BT-549 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.1670 -0.01383
BT-549 AZD7762
0.01
CHK1/2
Cell cycle
 1.1793 0.00066
BT-549 AZD7762
0.031623
CHK1/2
Cell cycle
 0.8788 0.11899
BT-549 AZD7762
0.1
CHK1/2
Cell cycle
 0.1731 0.28658
BT-549 AZD7762
0.31623
CHK1/2
Cell cycle
 -0.0478 0.29963
BT-549 AZD7762
1.0
CHK1/2
Cell cycle
 -0.1763 0.38276
BT-549 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.2965 0.40328
BT-549 AZD7762
10.0
CHK1/2
Cell cycle
 -0.4824 0.60829
BT-549 Volasertib
0.0001
PLK
Cell cycle
 1.0344 -0.00418
BT-549 Volasertib
0.00031623
PLK
Cell cycle
 1.0467 0.00107
BT-549 Volasertib
0.001
PLK
Cell cycle
 1.0041 0.00588
BT-549 Volasertib
0.0031623
PLK
Cell cycle
 0.9425 0.02789
BT-549 Volasertib
0.01
PLK
Cell cycle
 0.4084 0.12761
BT-549 Volasertib
0.031623
PLK
Cell cycle
 -0.0976 0.27861