Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1428 Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 0.0806 0.12908
HCC1428 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.0145 0.20173
HCC1428 Everolimus
0.001
mTOR1
PI3K/mTOR
 0.5609 0.01359
HCC1428 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.4972 0.01165
HCC1428 Everolimus
0.01
mTOR1
PI3K/mTOR
 0.5067 0.01479
HCC1428 Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.5265 0.01975
HCC1428 Everolimus
0.1
mTOR1
PI3K/mTOR
 0.5185 0.02165
HCC1428 Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.5092 0.02437
HCC1428 Everolimus
1.0
mTOR1
PI3K/mTOR
 0.4517 0.02431
HCC1428 Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.3880 0.01407
HCC1428 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.3462 0.02831
HCC1428 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 0.9695 0.00136
HCC1428 INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.8639 0.00380
HCC1428 INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.7180 0.01056
HCC1428 INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.3064 0.03089
HCC1428 INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.1846 0.06090
HCC1428 INK-128
0.1
mTORC1/2
PI3K/mTOR
 0.1163 0.06712
HCC1428 INK-128
0.31623
mTORC1/2
PI3K/mTOR
 0.1056 0.08294
HCC1428 INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.0342 0.09535
HCC1428 INK-128
3.1623
mTORC1/2
PI3K/mTOR
 -0.0001 0.11442
HCC1428 PF-4708671
0.001
p70S6K
PI3K/mTOR
 1.0190 0.00477
HCC1428 PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 1.0895 -0.00106
HCC1428 PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.1105 -0.00169
HCC1428 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0784 0.00181
HCC1428 PF-4708671
0.1
p70S6K
PI3K/mTOR
 1.0860 -0.00063