Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
Hs 578T AZD7762
0.0031623
CHK1/2
Cell cycle
 1.0447 0.01452
Hs 578T AZD7762
0.01
CHK1/2
Cell cycle
 0.6953 0.13036
Hs 578T AZD7762
0.031623
CHK1/2
Cell cycle
 0.0494 0.38164
Hs 578T AZD7762
0.1
CHK1/2
Cell cycle
 -0.2235 0.57267
Hs 578T AZD7762
0.31623
CHK1/2
Cell cycle
 -0.1923 0.55069
Hs 578T AZD7762
1.0
CHK1/2
Cell cycle
 -0.1765 0.54208
Hs 578T AZD7762
3.1623
CHK1/2
Cell cycle
 -0.3399 0.65876
Hs 578T AZD7762
10.0
CHK1/2
Cell cycle
 -0.5983 0.86377
Hs 578T Volasertib
0.0001
PLK
Cell cycle
 0.9564 -0.00165
Hs 578T Volasertib
0.00031623
PLK
Cell cycle
 0.9663 0.00418
Hs 578T Volasertib
0.001
PLK
Cell cycle
 0.9608 0.01359
Hs 578T Volasertib
0.0031623
PLK
Cell cycle
 0.2994 0.18889
Hs 578T Volasertib
0.01
PLK
Cell cycle
 -0.2484 0.51390
Hs 578T Volasertib
0.031623
PLK
Cell cycle
 -0.2839 0.59291
Hs 578T Volasertib
0.1
PLK
Cell cycle
 -0.2776 0.57923
Hs 578T Volasertib
0.31623
PLK
Cell cycle
 -0.3123 0.59818
Hs 578T Volasertib
1.0
PLK
Cell cycle
 -0.2818 0.51440
Hs 578T Dinaciclib
0.0001
pan CDK
Cell cycle
 0.9649 0.00169
Hs 578T Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0174 -0.00324
Hs 578T Dinaciclib
0.001
pan CDK
Cell cycle
 0.9941 0.00162
Hs 578T Dinaciclib
0.0031623
pan CDK
Cell cycle
 0.9971 0.00912
Hs 578T Dinaciclib
0.01
pan CDK
Cell cycle
 0.3304 0.18325
Hs 578T Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.2142 0.42143
Hs 578T Dinaciclib
0.1
pan CDK
Cell cycle
 -0.1968 0.43656
Hs 578T Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.2194 0.42321