Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| HME1 | Dasatinib | 3.1623 | BCR/ABL | MAPK/nRTK | -0.0053 | 0.08814 |
| SUM1315MO2 | Buparlisib | 3.1623 | pan PI3K | PI3K/mTOR | -0.3042 | 0.43925 |
| SK-BR-3 | Bleomycin | 3.1623 | Radiation | Misc | 0.3155 | 0.14104 |
| MDA-MB-453 | Ceritinib | 3.1623 | ALK | RTK | -0.5956 | 0.53319 |
| HCC1937 | Pictilisib | 3.1623 | pan PI3K | PI3K/mTOR | 0.4923 | 0.04773 |
| HCC1954 | Everolimus | 3.1623 | mTOR1 | PI3K/mTOR | 0.3263 | 0.13878 |
| MDA-MB-361 | Doxorubicin | 3.1623 | Chemo | Chemotherapy | -0.3088 | 0.17019 |
| SUM149PT | INK-128 | 3.1623 | mTORC1/2 | PI3K/mTOR | 0.2613 | 0.03984 |
| MCF 10A | PF-4708671 | 3.1623 | p70S6K | PI3K/mTOR | 0.8358 | -0.00533 |
| SK-BR-3 | Ipatasertib | 3.1623 | AKT | PI3K/mTOR | 0.5842 | 0.05390 |
| PDX1328 | Cisplatin | 3.1623 | Chemo | Chemotherapy | -0.0474 | 0.04196 |
| HCC1937 | Ceritinib | 3.1623 | ALK | RTK | 0.5946 | 0.04750 |
| MDA-MB-231 | Palbociclib | 3.1623 | CDK4/6 | Cell cycle | 0.2066 | 0.03980 |
| CAL-85-1 | ABT-737 | 3.1623 | Bcl2/XL | Misc | 0.9343 | 0.03598 |
| PDX1328 | Doxorubicin | 3.1623 | Chemo | Chemotherapy | -0.7789 | 0.65064 |
| SUM149PT | PF-4708671 | 3.1623 | p70S6K | PI3K/mTOR | 0.9238 | 0.00901 |
| SK-BR-3 | Alpelisib | 3.1623 | PI3Ka | PI3K/mTOR | 0.2183 | 0.11201 |
| HME1 | ABT-737 | 3.1623 | Bcl2/XL | Misc | 0.4949 | 0.08784 |
| HME1 | Saracatinib | 3.1623 | SRC | MAPK/nRTK | 0.9252 | -0.00464 |
| PDX1328 | Topotecan | 3.1623 | Topo I | Chemotherapy | -0.7394 | 0.40003 |
| Hs 578T | ABT-737 | 3.1623 | Bcl2/XL | Misc | 0.8838 | 0.03824 |
| MCF 10A | Buparlisib | 3.1623 | pan PI3K | PI3K/mTOR | 0.0988 | 0.10554 |
| SK-BR-3 | Taselisib | 3.1623 | PI3Ka, g, d | PI3K/mTOR | -0.0551 | 0.21381 |
| CAL-51 | Alpelisib | 3.1623 | PI3Ka | PI3K/mTOR | 0.6991 | 0.03349 |
| HCC1419 | Cisplatin | 3.1623 | Chemo | Chemotherapy | 0.3059 | -0.00310 |