Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-436 Cediranib
10.0
VEGFR/cKIT
RTK
 -0.3824 0.39722
CAMA-1 Volasertib
0.1
PLK
Cell cycle
 -0.3812 0.53477
CAMA-1 Etoposide
3.1623
Topo II
Chemotherapy
 -0.3802 0.45373
SUM159PT Ceritinib
10.0
ALK
RTK
 -0.3800 0.80163
CAMA-1 Dinaciclib
0.1
pan CDK
Cell cycle
 -0.3799 0.45483
MDA-MB-468 Volasertib
0.01
PLK
Cell cycle
 -0.3797 0.64007
CAL-85-1 Luminespib
0.1
HSP90
Misc
 -0.3793 0.56133
HCC1954 Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.3790 0.64694
CAL-85-1 Doxorubicin
1.0
Chemo
Chemotherapy
 -0.3783 0.43963
SUM149PT Luminespib
0.1
HSP90
Misc
 -0.3767 0.68080
CAL-85-1 Luminespib
0.31623
HSP90
Misc
 -0.3765 0.56828
HCC1428 Topotecan
10.0
Topo I
Chemotherapy
 -0.3764 0.49642
HCC1806 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.3761 0.66396
Hs 578T Taxol
1.0
Chemo
Chemotherapy
 -0.3752 0.74970
BT-20 Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 -0.3749 0.60583
HCC1954 Luminespib
1.0
HSP90
Misc
 -0.3745 0.65805
HCC38 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.3744 0.44124
SUM149PT Luminespib
0.31623
HSP90
Misc
 -0.3744 0.67001
MDA-MB-361 AZD7762
0.1
CHK1/2
Cell cycle
 -0.3743 0.24817
MDA-MB-453 Pictilisib
10.0
pan PI3K
PI3K/mTOR
 -0.3736 0.38023
MDA-MB-361 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.3733 0.23979
SK-BR-3 Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.3731 0.45147
PDXHCI002 Tivantinib
1.0
MET
RTK
 -0.3731 0.60360
CAL-85-1 Luminespib
0.031623
HSP90
Misc
 -0.3724 0.57889
HCC1419 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.3722 0.38672