Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-468 Topotecan
3.1623
Topo I
Chemotherapy
 -0.6577 0.79091
CAMA-1 Doxorubicin
3.1623
Chemo
Chemotherapy
 -0.6517 0.79195
Hs 578T Topotecan
10.0
Topo I
Chemotherapy
 -0.4488 0.79649
MDA-MB-468 Topotecan
1.0
Topo I
Chemotherapy
 -0.6652 0.79819
SUM159PT Ceritinib
10.0
ALK
RTK
 -0.3800 0.80163
MDA-MB-134-VI Ceritinib
10.0
ALK
RTK
 -0.9992 0.80386
BT-20 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.6706 0.80415
MDA-MB-361 Pictilisib
10.0
pan PI3K
PI3K/mTOR
 -0.9375 0.80430
PDXHCI002 Doxorubicin
1.0
Chemo
Chemotherapy
 -0.6545 0.80551
MDA-MB-468 Taxol
0.1
Chemo
Chemotherapy
 -0.5472 0.80695
MDA-MB-134-VI Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.9986 0.81070
Hs 578T Cediranib
10.0
VEGFR/cKIT
RTK
 -0.5723 0.81093
SUM149PT Dinaciclib
1.0
pan CDK
Cell cycle
 -0.5605 0.81650
MDA-MB-361 Vorinostat
10.0
HDAC
Misc
 -0.9392 0.81668
BT-20 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.6979 0.82310
SUM149PT Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.5676 0.82399
MDA-MB-361 Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 -0.9425 0.82696
HCC1428 Doxorubicin
3.1623
Chemo
Chemotherapy
 -0.7396 0.82745
MDA-MB-134-VI Cediranib
10.0
VEGFR/cKIT
RTK
 -0.9999 0.83082
SUM149PT Dinaciclib
0.1
pan CDK
Cell cycle
 -0.5705 0.83197
MDA-MB-157 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.9006 0.83378
MDA-MB-157 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.9106 0.83515
HCC1428 Ceritinib
10.0
ALK
RTK
 -0.8673 0.83636
MDA-MB-468 Ceritinib
10.0
ALK
RTK
 -0.7415 0.83751
MDA-MB-157 Ceritinib
10.0
ALK
RTK
 -0.9264 0.83901