Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
BT-549 Vorinostat
0.1
HDAC
Misc
 0.9070 -0.00670
CAMA-1 Abemaciclib
0.01
CDK4/6
Cell cycle
 0.4456 -0.00670
CAL-85-1 Ceritinib
0.01
ALK
RTK
 0.9540 -0.00669
MDA-MB-436 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0259 -0.00668
MDA-MB-468 Olaparib
0.031623
PARP
Misc
 1.0329 -0.00668
HCC1500 Ipatasertib
0.001
AKT
PI3K/mTOR
 1.1106 -0.00668
HCC1419 Palbociclib
0.01
CDK4/6
Cell cycle
 0.8976 -0.00667
SK-BR-3 Saracatinib
0.01
SRC
MAPK/nRTK
 1.1099 -0.00667
MCF 10A Abemaciclib
0.01
CDK4/6
Cell cycle
 0.8774 -0.00666
SUM1315MO2 Cisplatin
0.01
Chemo
Chemotherapy
 0.8236 -0.00666
BT-20 TGX221
1.0
PI3Kb
PI3K/mTOR
 1.1067 -0.00666
SK-BR-3 A-1210477
1.0
Mcl-1
Misc
 0.9969 -0.00665
PDX1328 Ipatasertib
0.01
AKT
PI3K/mTOR
 1.2222 -0.00663
MDA-MB-134-VI Cabozantinib
3.1623
VEGFR2/MET
RTK
 1.2303 -0.00662
CAL-120 Alpelisib
0.31623
PI3Ka
PI3K/mTOR
 0.9227 -0.00661
HCC1419 Saracatinib
0.0031623
SRC
MAPK/nRTK
 1.0841 -0.00660
CAMA-1 Etoposide
0.01
Topo II
Chemotherapy
 1.0564 -0.00659
MCF 10A Taselisib
0.1
PI3Ka, g, d
PI3K/mTOR
 0.5033 -0.00658
HCC38 Volasertib
0.001
PLK
Cell cycle
 1.1053 -0.00658
HCC1954 Luminespib
0.00031623
HSP90
Misc
 1.0879 -0.00654
HCC38 Cabozantinib
3.1623
VEGFR2/MET
RTK
 0.9835 -0.00654
HCC1143 Palbociclib
0.01
CDK4/6
Cell cycle
 0.9533 -0.00651
BT-549 Tivantinib
0.01
MET
RTK
 1.0764 -0.00650
BT-549 Palbociclib
1.0
CDK4/6
Cell cycle
 1.0826 -0.00648
HCC1419 Trametinib
0.31623
MEK
MAPK/nRTK
 0.4368 -0.00647