Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
CAL-51 Bleomycin
0.0010833
Radiation
Misc
 1.0032 -0.01035
HCC1500 Palbociclib
0.0031623
CDK4/6
Cell cycle
 1.2141 -0.01034
HCC1806 Etoposide
0.0033333
Topo II
Chemotherapy
 1.0136 -0.01034
PDX1328 Palbociclib
0.0031623
CDK4/6
Cell cycle
 1.1768 -0.01033
PDXHCI002 Neratinib
0.1
EGFR/HER2
RTK
 0.5417 -0.01033
PDXHCI002 Olaparib
0.01
PARP
Misc
 0.9830 -0.01030
HCC70 Abemaciclib
0.031623
CDK4/6
Cell cycle
 1.1572 -0.01029
PDXHCI002 TGX221
0.0031623
PI3Kb
PI3K/mTOR
 1.1060 -0.01029
PDXHCI002 Abemaciclib
0.001
CDK4/6
Cell cycle
 1.0814 -0.01026
HCC1954 Abemaciclib
0.001
CDK4/6
Cell cycle
 0.9957 -0.01026
PDXHCI002 Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.6468 -0.01025
HCC1419 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.5337 -0.01021
HCC1954 Cabozantinib
0.01
VEGFR2/MET
RTK
 1.0562 -0.01011
HCC1954 Cisplatin
0.0010833
Chemo
Chemotherapy
 1.0111 -0.01008
CAL-85-1 Taselisib
0.001
PI3Ka, g, d
PI3K/mTOR
 0.8588 -0.01008
HCC1954 Palbociclib
0.031623
CDK4/6
Cell cycle
 0.8506 -0.01007
HCC1806 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.8953 -0.01004
SUM1315MO2 Cisplatin
0.031667
Chemo
Chemotherapy
 0.9423 -0.01003
MDA-MB-134-VI Etoposide
0.1
Topo II
Chemotherapy
 0.4957 -0.01003
HCC1806 PF-4708671
1.0
p70S6K
PI3K/mTOR
 1.0192 -0.00999
CAL-120 TGX221
0.31623
PI3Kb
PI3K/mTOR
 1.0346 -0.00999
HCC70 Palbociclib
3.1623
CDK4/6
Cell cycle
 0.9361 -0.00999
HCC1954 Luminespib
0.0031623
HSP90
Misc
 1.0434 -0.00998
HCC38 Cisplatin
0.0033333
Chemo
Chemotherapy
 1.0467 -0.00993
HCC1419 Trametinib
0.031623
MEK
MAPK/nRTK
 0.4571 -0.00992