Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
CAL-85-1 Saracatinib
0.001
SRC
MAPK/nRTK
 1.1030 -0.00387
HCC1500 Palbociclib
0.01
CDK4/6
Cell cycle
 1.1029 0.00511
PDXHCI002 Everolimus
0.1
mTOR1
PI3K/mTOR
 1.1029 -0.05190
HCC70 Saracatinib
0.0031623
SRC
MAPK/nRTK
 1.1029 -0.00166
PDXHCI002 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.1026 -0.00272
MDA-MB-361 ABT-737
0.31623
Bcl2/XL
Misc
 1.1026 0.00029
HCC70 Dinaciclib
0.001
pan CDK
Cell cycle
 1.1024 -0.00085
HCC1395 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.1023 0.00621
MDA-MB-453 Vorinostat
0.1
HDAC
Misc
 1.1022 -0.00059
PDXHCI002 Dinaciclib
0.001
pan CDK
Cell cycle
 1.1022 -0.00350
MDA-MB-361 ABT-737
0.01
Bcl2/XL
Misc
 1.1022 0.00045
MDA-MB-361 Volasertib
0.0001
PLK
Cell cycle
 1.1018 -0.00630
HME1 AZD7762
0.031623
CHK1/2
Cell cycle
 1.1018 0.04648
CAL-85-1 Palbociclib
0.1
CDK4/6
Cell cycle
 1.1017 0.00514
PDX1328 ABT-737
0.0031623
Bcl2/XL
Misc
 1.1016 0.01154
MDA-MB-453 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.1016 0.00226
PDX1258 Palbociclib
0.031623
CDK4/6
Cell cycle
 1.1013 0.00271
MDA-MB-436 Dinaciclib
0.0031623
pan CDK
Cell cycle
 1.1013 0.00430
T47D Dinaciclib
0.0031623
pan CDK
Cell cycle
 1.1013 -0.00122
MDA-MB-453 Cisplatin
0.31623
Chemo
Chemotherapy
 1.1010 -0.02007
HCC1428 Tivantinib
0.0031623
MET
RTK
 1.1007 -0.00420
HCC1395 Cediranib
0.031623
VEGFR/cKIT
RTK
 1.1006 -0.00077
MDA-MB-361 Dinaciclib
0.0031623
pan CDK
Cell cycle
 1.1006 0.00107
HCC1954 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.1006 -0.00938
MDA-MB-361 A-1210477
0.31623
Mcl-1
Misc
 1.1005 0.00191