Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-453 Cabozantinib
0.001
VEGFR2/MET
RTK
 1.1531 0.01205
HCC1500 Buparlisib
0.001
pan PI3K
PI3K/mTOR
 1.1529 0.00448
HCC70 Ceritinib
0.0031623
ALK
RTK
 1.1527 0.00335
MDA-MB-453 Vorinostat
0.031623
HDAC
Misc
 1.1522 0.02043
PDX1328 Olaparib
0.0031623
PARP
Misc
 1.1511 -0.01286
PDX1328 Ceritinib
0.0031623
ALK
RTK
 1.1506 0.00069
HCC1954 Cabozantinib
0.31623
VEGFR2/MET
RTK
 1.1505 -0.01637
HCC1806 PF-4708671
3.1623
p70S6K
PI3K/mTOR
 1.1503 -0.01604
HCC1500 Ipatasertib
0.01
AKT
PI3K/mTOR
 1.1500 0.00530
PDX1328 Tivantinib
0.0031623
MET
RTK
 1.1499 0.00008
HCC70 TGX221
0.001
PI3Kb
PI3K/mTOR
 1.1498 0.00566
HCC70 Vorinostat
0.0031623
HDAC
Misc
 1.1496 0.00738
MDA-MB-361 TGX221
0.01
PI3Kb
PI3K/mTOR
 1.1495 0.00358
MDA-MB-453 TGX221
0.01
PI3Kb
PI3K/mTOR
 1.1494 0.01199
HCC70 ABT-737
0.01
Bcl2/XL
Misc
 1.1492 0.00319
HCC1500 Ceritinib
0.001
ALK
RTK
 1.1491 0.00774
MDA-MB-134-VI A-1210477
0.031623
Mcl-1
Misc
 1.1486 -0.00249
MDA-MB-134-VI Olaparib
0.031623
PARP
Misc
 1.1486 -0.00032
PDX1328 Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.1480 -0.00168
MDA-MB-453 A-1210477
0.001
Mcl-1
Misc
 1.1479 0.02197
PDX1258 Dinaciclib
0.001
pan CDK
Cell cycle
 1.1478 -0.00260
HCC70 Cediranib
0.0031623
VEGFR/cKIT
RTK
 1.1477 -0.00137
MDA-MB-453 A-1210477
0.1
Mcl-1
Misc
 1.1460 0.02865
T47D ABT-737
0.31623
Bcl2/XL
Misc
 1.1459 0.00138
HCC1428 AZD7762
0.01
CHK1/2
Cell cycle
 1.1457 0.00219