Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| SUM1315MO2 | Abemaciclib | 0.01 | CDK4/6 | Cell cycle | 0.7121 | -0.00006 |
| SUM1315MO2 | Abemaciclib | 0.031623 | CDK4/6 | Cell cycle | 0.4510 | 0.01944 |
| SUM1315MO2 | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.3858 | 0.01731 |
| SUM1315MO2 | Abemaciclib | 0.31623 | CDK4/6 | Cell cycle | 0.2593 | 0.02543 |
| SUM1315MO2 | Abemaciclib | 1.0 | CDK4/6 | Cell cycle | 0.1952 | 0.02708 |
| SUM1315MO2 | Abemaciclib | 3.1623 | CDK4/6 | Cell cycle | 0.1030 | 0.02380 |
| SUM1315MO2 | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.1445 | 0.14383 |
| SUM1315MO2 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 1.0704 | -0.00082 |
| SUM1315MO2 | Palbociclib | 0.001 | CDK4/6 | Cell cycle | 0.9810 | -0.00359 |
| SUM1315MO2 | Palbociclib | 0.0031623 | CDK4/6 | Cell cycle | 0.9092 | -0.00352 |
| SUM1315MO2 | Palbociclib | 0.01 | CDK4/6 | Cell cycle | 0.8607 | 0.00206 |
| SUM1315MO2 | Palbociclib | 0.031623 | CDK4/6 | Cell cycle | 0.6245 | 0.01210 |
| SUM1315MO2 | Palbociclib | 0.1 | CDK4/6 | Cell cycle | 0.5170 | 0.02037 |
| SUM1315MO2 | Palbociclib | 0.31623 | CDK4/6 | Cell cycle | 0.3767 | 0.02199 |
| SUM1315MO2 | Palbociclib | 1.0 | CDK4/6 | Cell cycle | 0.4047 | 0.02086 |
| SUM1315MO2 | Palbociclib | 3.1623 | CDK4/6 | Cell cycle | 0.3001 | 0.03387 |
| SUM1315MO2 | AZD7762 | 0.001 | CHK1/2 | Cell cycle | 1.1615 | -0.00361 |
| SUM1315MO2 | AZD7762 | 0.0031623 | CHK1/2 | Cell cycle | 1.0758 | -0.00008 |
| SUM1315MO2 | AZD7762 | 0.01 | CHK1/2 | Cell cycle | 1.1343 | 0.01760 |
| SUM1315MO2 | AZD7762 | 0.031623 | CHK1/2 | Cell cycle | 0.5593 | 0.11440 |
| SUM1315MO2 | AZD7762 | 0.1 | CHK1/2 | Cell cycle | 0.1468 | 0.19864 |
| SUM1315MO2 | AZD7762 | 0.31623 | CHK1/2 | Cell cycle | -0.0659 | 0.23559 |
| SUM1315MO2 | AZD7762 | 1.0 | CHK1/2 | Cell cycle | -0.1812 | 0.29971 |
| SUM1315MO2 | AZD7762 | 3.1623 | CHK1/2 | Cell cycle | -0.3637 | 0.33806 |
| SUM1315MO2 | AZD7762 | 10.0 | CHK1/2 | Cell cycle | -0.6526 | 0.66363 |