Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1428 Saracatinib
1.0
SRC
MAPK/nRTK
 0.8482 0.01220
HCC1428 Saracatinib
3.1623
SRC
MAPK/nRTK
 0.7726 0.01406
HCC1428 Saracatinib
10.0
SRC
MAPK/nRTK
 0.6691 0.03066
HCC1428 ABT-737
0.001
Bcl2/XL
Misc
 0.9882 0.00240
HCC1428 ABT-737
0.0031623
Bcl2/XL
Misc
 1.0025 0.00091
HCC1428 ABT-737
0.01
Bcl2/XL
Misc
 1.0298 0.00766
HCC1428 ABT-737
0.031623
Bcl2/XL
Misc
 1.0952 0.01929
HCC1428 ABT-737
0.1
Bcl2/XL
Misc
 1.0724 0.03530
HCC1428 ABT-737
0.31623
Bcl2/XL
Misc
 0.9194 0.05289
HCC1428 ABT-737
1.0
Bcl2/XL
Misc
 0.7879 0.09899
HCC1428 ABT-737
3.1623
Bcl2/XL
Misc
 0.5898 0.15454
HCC1428 ABT-737
10.0
Bcl2/XL
Misc
 0.2431 0.27285
HCC1428 Vorinostat
0.001
HDAC
Misc
 1.0625 -0.00070
HCC1428 Vorinostat
0.0031623
HDAC
Misc
 0.9816 -0.00071
HCC1428 Vorinostat
0.01
HDAC
Misc
 0.9998 0.00365
HCC1428 Vorinostat
0.031623
HDAC
Misc
 0.9919 0.00121
HCC1428 Vorinostat
0.1
HDAC
Misc
 0.9292 -0.00163
HCC1428 Vorinostat
0.31623
HDAC
Misc
 0.8935 -0.00058
HCC1428 Vorinostat
1.0
HDAC
Misc
 0.3747 0.04712
HCC1428 Vorinostat
3.1623
HDAC
Misc
 -0.1756 0.35183
HCC1428 Vorinostat
10.0
HDAC
Misc
 -0.4792 0.51969
HCC1428 Luminespib
0.0001
HSP90
Misc
 0.9793 0.00315
HCC1428 Luminespib
0.00031623
HSP90
Misc
 1.0335 -0.00523
HCC1428 Luminespib
0.001
HSP90
Misc
 1.0185 0.00429
HCC1428 Luminespib
0.0031623
HSP90
Misc
 0.3771 0.05669