Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
Hs 578T Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.4324 0.03162
Hs 578T Everolimus
0.1
mTOR1
PI3K/mTOR
 0.5038 0.01831
Hs 578T Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.4903 0.01660
Hs 578T Everolimus
1.0
mTOR1
PI3K/mTOR
 0.4443 0.03625
Hs 578T Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.4204 0.02004
Hs 578T Everolimus
10.0
mTOR1
PI3K/mTOR
 0.4408 0.04195
Hs 578T INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 0.9166 0.00286
Hs 578T INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.9279 -0.00073
Hs 578T INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.8314 -0.00098
Hs 578T INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.4391 0.03288
Hs 578T INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.1792 0.07770
Hs 578T INK-128
0.1
mTORC1/2
PI3K/mTOR
 0.0933 0.14182
Hs 578T INK-128
0.31623
mTORC1/2
PI3K/mTOR
 0.0920 0.14671
Hs 578T INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.0330 0.20747
Hs 578T INK-128
3.1623
mTORC1/2
PI3K/mTOR
 -0.0708 0.30146
Hs 578T PF-4708671
0.001
p70S6K
PI3K/mTOR
 1.0144 0.00572
Hs 578T PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 0.9828 0.00002
Hs 578T PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.0280 0.00023
Hs 578T PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0346 0.00244
Hs 578T PF-4708671
0.1
p70S6K
PI3K/mTOR
 0.9697 -0.00116
Hs 578T PF-4708671
0.31623
p70S6K
PI3K/mTOR
 0.9558 0.00654
Hs 578T PF-4708671
1.0
p70S6K
PI3K/mTOR
 0.9332 -0.00293
Hs 578T PF-4708671
3.1623
p70S6K
PI3K/mTOR
 0.9143 0.00133
Hs 578T PF-4708671
10.0
p70S6K
PI3K/mTOR
 0.9455 -0.00768
Hs 578T Buparlisib
0.001
pan PI3K
PI3K/mTOR
 0.9764 0.00362