LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Taxol | 58.58 | 13.3 | 0.0017 | 0.0018 | -0.2303 | -0.1683 | 4.8617 | 0.6739 |
| MCF 10A-H2B-mCherry | Taxol | 60.80 | 13.3 | 0.0017 | 0.0018 | -0.1470 | -0.1634 | 4.7707 | 0.6633 |
| MCF 10A-H2B-mCherry | Taxol | 63.02 | 13.3 | 0.0018 | 0.0018 | 0.0879 | -0.0920 | 5.0000 | 0.6130 |
| MCF 10A-H2B-mCherry | Taxol | 65.24 | 13.3 | 0.002 | 0.0022 | -0.3431 | -0.2472 | 4.2654 | 0.7033 |
| MCF 10A-H2B-mCherry | Taxol | 67.47 | 13.3 | 0.0019 | 0.002 | -0.1129 | -0.0505 | 5.0000 | 0.6016 |
| MCF 10A-H2B-mCherry | Taxol | 69.71 | 13.4 | 0.0023 | 0.0025 | -0.2735 | -0.1573 | 4.8802 | 0.6351 |
| MCF 10A-H2B-mCherry | Taxol | 71.94 | 13.4 | 0.0024 | 0.0025 | -0.4059 | -0.1917 | 5.0000 | 0.6660 |
| MCF 10A-H2B-mCherry | Taxol | 74.16 | 13.4 | 0.0024 | 0.0026 | -0.2040 | -0.1914 | 4.6471 | 0.6619 |
| MCF 10A-H2B-mCherry | Taxol | 76.38 | 13.4 | 0.0027 | 0.003 | -0.3872 | -0.2827 | 5.0000 | 0.7081 |
| MCF 10A-H2B-mCherry | Taxol | 78.60 | 13.4 | 0.0027 | 0.003 | -0.4567 | -0.3897 | 5.0000 | 0.7535 |
| MCF 10A-H2B-mCherry | Taxol | 80.82 | 13.4 | 0.0029 | 0.0033 | -0.4208 | -0.4210 | 5.0000 | 0.7492 |
| MCF 10A-H2B-mCherry | Trametinib | 15.91 | 13.5 | 0.0058 | 0.003 | 0.3307 | 0.3502 | 1.7943 | 0.4481 |
| MCF 10A-H2B-mCherry | Trametinib | 16.73 | 13.3 | 0.0054 | 0.0032 | 0.1822 | 0.2568 | 1.3893 | 0.5061 |
| MCF 10A-H2B-mCherry | Trametinib | 18.59 | 13.3 | 0.0031 | 0.0024 | 0.1609 | 0.1780 | 1.5913 | 0.5859 |
| MCF 10A-H2B-mCherry | Trametinib | 20.81 | 13.3 | 0.0023 | 0.0021 | 0.0576 | 0.0696 | 1.6693 | 0.6766 |
| MCF 10A-H2B-mCherry | Trametinib | 23.04 | 13.3 | 0.0021 | 0.0021 | -0.0007 | 0.0178 | 1.5525 | 0.7172 |
| MCF 10A-H2B-mCherry | Trametinib | 25.25 | 13.3 | 0.0022 | 0.0022 | -0.0214 | -0.0002 | 1.6675 | 0.7253 |
| MCF 10A-H2B-mCherry | Trametinib | 27.48 | 13.3 | 0.0023 | 0.0023 | -0.0296 | -0.0065 | 1.5175 | 0.7195 |
| MCF 10A-H2B-mCherry | Trametinib | 29.70 | 13.3 | 0.0026 | 0.0026 | -0.0081 | 0.0005 | 1.4257 | 0.7007 |
| MCF 10A-H2B-mCherry | Trametinib | 31.92 | 13.3 | 0.0029 | 0.003 | 0.0010 | -0.0067 | 1.2681 | 0.6896 |
| MCF 10A-H2B-mCherry | Trametinib | 34.14 | 13.3 | 0.0035 | 0.0036 | -0.0098 | -0.0135 | 1.1220 | 0.6699 |
| MCF 10A-H2B-mCherry | Trametinib | 36.36 | 13.3 | 0.0039 | 0.0039 | 0.0199 | 0.0015 | 1.1076 | 0.6499 |
| MCF 10A-H2B-mCherry | Trametinib | 38.59 | 13.3 | 0.005 | 0.0052 | 0.0005 | -0.0200 | 0.9820 | 0.6323 |
| MCF 10A-H2B-mCherry | Trametinib | 40.81 | 13.3 | 0.0061 | 0.0062 | 0.0257 | -0.0045 | 1.0021 | 0.6032 |
| MCF 10A-H2B-mCherry | Trametinib | 43.03 | 13.3 | 0.0081 | 0.0081 | 0.0108 | -0.0039 | 1.0504 | 0.5720 |