LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Trametinib 45.25 13.3
0.0119
0.0117
 0.0297 0.0122 1.2484 0.5302
MCF 10A-H2B-mCherry Trametinib 47.47 13.3
0.014
0.0132
 0.0446 0.0490 1.9591 0.5006
MCF 10A-H2B-mCherry Trametinib 49.69 13.3
0.0178
0.017
 0.0450 0.0418 2.0225 0.4779
MCF 10A-H2B-mCherry Trametinib 51.92 13.3
0.0175
0.0167
 0.0376 0.0432 1.9155 0.4714
MCF 10A-H2B-mCherry Trametinib 54.14 13.3
0.018
0.0175
 0.0175 0.0215 1.8780 0.4726
MCF 10A-H2B-mCherry Trametinib 56.36 13.3
0.0178
0.0174
 0.0306 0.0301 2.2588 0.4660
MCF 10A-H2B-mCherry Trametinib 58.58 13.3
0.019
0.0186
 0.0026 0.0225 2.1563 0.4585
MCF 10A-H2B-mCherry Trametinib 60.80 13.3
0.0203
0.0196
 0.0037 0.0448 2.6253 0.4458
MCF 10A-H2B-mCherry Trametinib 63.02 13.3
0.0192
0.0188
 -0.0159 0.0290 2.7555 0.4494
MCF 10A-H2B-mCherry Trametinib 65.24 13.3
0.0216
0.0211
 0.0017 0.0439 4.0050 0.4213
MCF 10A-H2B-mCherry Trametinib 67.47 13.3
0.0241
0.0235
 0.0230 0.0543 4.6584 0.4056
MCF 10A-H2B-mCherry Trametinib 69.71 13.4
0.0283
0.0275
 -0.0156 0.0459 4.2625 0.3921
MCF 10A-H2B-mCherry Trametinib 71.94 13.4
0.0301
0.0295
 -0.0284 0.0490 5.0000 0.3826
MCF 10A-H2B-mCherry Trametinib 74.16 13.4
0.0303
0.0298
 -0.0034 0.0350 5.0000 0.3753
MCF 10A-H2B-mCherry Trametinib 76.38 13.4
0.0309
0.0305
 -0.0623 0.0243 5.0000 0.3705
MCF 10A-H2B-mCherry Trametinib 78.60 13.4
0.0337
0.0328
 0.0005 0.0659 5.0000 0.3496
MCF 10A-H2B-mCherry Trametinib 80.82 13.4
0.0466
0.0449
 0.0168 0.0770 4.4772 0.3291
MCF 10A-H2B-mCherry Vorinostat 15.91 13.5
0.673
1.0022
 -0.2338 -0.3147 1.2258 0.4090
MCF 10A-H2B-mCherry Vorinostat 16.73 13.3
0.6881
1.3581
 -0.2534 -0.4659 0.9685 0.4010
MCF 10A-H2B-mCherry Vorinostat 18.59 13.3
0.5664
1.0687
 -0.2412 -0.4101 0.9460 0.4283
MCF 10A-H2B-mCherry Vorinostat 20.81 13.3
0.502
0.8536
 -0.2101 -0.3304 0.9626 0.4380
MCF 10A-H2B-mCherry Vorinostat 23.04 13.3
0.5079
0.7078
 -0.1692 -0.2294 1.1387 0.4288
MCF 10A-H2B-mCherry Vorinostat 25.25 13.3
0.5644
0.7187
 -0.1603 -0.1877 1.3197 0.4052
MCF 10A-H2B-mCherry Vorinostat 27.48 13.3
0.6823
0.8212
 -0.1496 -0.1683 1.6127 0.3903
MCF 10A-H2B-mCherry Vorinostat 29.70 13.3
0.765
0.8757
 -0.1253 -0.1391 1.8944 0.3675