LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Palbociclib | 71.94 | 13.4 | 2.7362 | 2.5853 | 0.0380 | 0.0561 | 2.5907 | 0.1209 |
| MCF 10A-H2B-mCherry | Palbociclib | 74.16 | 13.4 | 3.0756 | 2.9316 | 0.0118 | 0.0580 | 3.5445 | 0.1026 |
| MCF 10A-H2B-mCherry | Palbociclib | 76.38 | 13.4 | 3.7937 | 3.9931 | 0.0653 | -0.0691 | 2.1758 | 0.1012 |
| MCF 10A-H2B-mCherry | Palbociclib | 78.60 | 13.4 | 3.8114 | 5.377 | -0.0290 | -0.5698 | 2.1381 | 0.1010 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.82 | 13.4 | 4.3569 | 6.7523 | -0.0503 | -0.7295 | 1.9672 | 0.0940 |
| MCF 10A-H2B-mCherry | Taxol | 15.91 | 13.5 | 0.0055 | 0.0121 | -0.6952 | -0.7201 | 1.1326 | 0.6312 |
| MCF 10A-H2B-mCherry | Taxol | 16.73 | 13.3 | 0.0047 | 0.0097 | -0.6834 | -0.7046 | 1.2187 | 0.6742 |
| MCF 10A-H2B-mCherry | Taxol | 18.59 | 13.3 | 0.0034 | 0.0077 | -0.7352 | -0.7179 | 1.1107 | 0.7117 |
| MCF 10A-H2B-mCherry | Taxol | 20.81 | 13.3 | 0.0024 | 0.0055 | -0.7843 | -0.7290 | 1.0789 | 0.7803 |
| MCF 10A-H2B-mCherry | Taxol | 23.04 | 13.3 | 0.002 | 0.0039 | -0.7844 | -0.6681 | 1.2967 | 0.8096 |
| MCF 10A-H2B-mCherry | Taxol | 25.25 | 13.3 | 0.0019 | 0.0035 | -0.7891 | -0.6591 | 1.4064 | 0.8233 |
| MCF 10A-H2B-mCherry | Taxol | 27.48 | 13.3 | 0.0019 | 0.0032 | -0.7766 | -0.6351 | 1.5305 | 0.8280 |
| MCF 10A-H2B-mCherry | Taxol | 29.70 | 13.3 | 0.0018 | 0.0028 | -0.7417 | -0.6033 | 1.6514 | 0.8307 |
| MCF 10A-H2B-mCherry | Taxol | 31.92 | 13.3 | 0.0016 | 0.0025 | -0.6609 | -0.5655 | 1.5990 | 0.8378 |
| MCF 10A-H2B-mCherry | Taxol | 34.14 | 13.3 | 0.0015 | 0.0022 | -0.6309 | -0.4906 | 1.7169 | 0.8190 |
| MCF 10A-H2B-mCherry | Taxol | 36.36 | 13.3 | 0.0014 | 0.002 | -0.5106 | -0.4415 | 1.8237 | 0.8179 |
| MCF 10A-H2B-mCherry | Taxol | 38.59 | 13.3 | 0.0013 | 0.0018 | -0.5016 | -0.3717 | 2.0884 | 0.8013 |
| MCF 10A-H2B-mCherry | Taxol | 40.81 | 13.3 | 0.0013 | 0.0017 | -0.3971 | -0.3361 | 2.3974 | 0.7895 |
| MCF 10A-H2B-mCherry | Taxol | 43.03 | 13.3 | 0.0014 | 0.0016 | -0.3983 | -0.2791 | 2.7072 | 0.7654 |
| MCF 10A-H2B-mCherry | Taxol | 45.25 | 13.3 | 0.0014 | 0.0016 | -0.2993 | -0.2321 | 3.0578 | 0.7257 |
| MCF 10A-H2B-mCherry | Taxol | 47.47 | 13.3 | 0.0014 | 0.0016 | -0.3185 | -0.2225 | 3.3773 | 0.7193 |
| MCF 10A-H2B-mCherry | Taxol | 49.69 | 13.3 | 0.0016 | 0.0017 | -0.3046 | -0.2186 | 3.6106 | 0.7027 |
| MCF 10A-H2B-mCherry | Taxol | 51.92 | 13.3 | 0.0016 | 0.0016 | 0.0999 | -0.0736 | 4.3434 | 0.6212 |
| MCF 10A-H2B-mCherry | Taxol | 54.14 | 13.3 | 0.0016 | 0.0017 | -0.1153 | -0.1257 | 4.3153 | 0.6536 |
| MCF 10A-H2B-mCherry | Taxol | 56.36 | 13.3 | 0.0016 | 0.0017 | -0.1584 | -0.1428 | 4.2867 | 0.6635 |