Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 3369 247 1.0671 1.0367 0.0733 0.0669
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1496 94 0.4792 1.0367 0.0628 0.0669
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 716 194 0.1784 0.2639 0.2709 0.2819
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 1201 355 0.2892 0.2639 0.2956 0.2819
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 1315 367 0.3240 0.2639 0.2791 0.2819
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 868 299 0.1945 0.2831 0.3445 0.3131
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1271 412 0.2936 0.2831 0.3242 0.3131
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1449 392 0.3613 0.2831 0.2705 0.3131
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1270 318 0.3254 0.2386 0.2504 0.2568
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 1056 294 0.2605 0.2386 0.2784 0.2568
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 501 121 0.1299 0.2386 0.2415 0.2568
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1611 342 0.4337 0.2967 0.2123 0.2275
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1208 299 0.3107 0.2967 0.2475 0.2275
MZ7-mel Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 548 122 0.1456 0.2967 0.2226 0.2275
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 968 340 0.2147 0.2772 0.3512 0.3662
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 1284 498 0.2687 0.2772 0.3879 0.3662
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1591 572 0.3483 0.2772 0.3595 0.3662
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 802 298 0.1723 0.2182 0.3716 0.3712
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 910 342 0.1941 0.2182 0.3758 0.3712
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 1330 487 0.2881 0.2182 0.3662 0.3712
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1684 564 0.3828 0.2403 0.3349 0.3512
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 1079 362 0.2451 0.2403 0.3355 0.3512
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 441 169 0.0930 0.2403 0.3832 0.3512
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1207 333 0.2987 0.2137 0.2759 0.2920
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 951 314 0.2177 0.2137 0.3302 0.2920