Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 3565 254 0.9932 1.0000 0.0712 0.0694
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 3443 247 0.9587 1.0000 0.0717 0.0694
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 3738 244 1.0481 1.0000 0.0653 0.0694
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1001 55 0.2838 0.3534 0.0549 0.0527
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1014 59 0.2865 0.3534 0.0582 0.0527
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1710 77 0.4899 0.3534 0.0450 0.0527
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 1064 67 0.2991 0.2356 0.0630 0.0441
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 649 22 0.1881 0.2356 0.0339 0.0441
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 759 27 0.2196 0.2356 0.0356 0.0441
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2061 127 0.5801 0.3687 0.0616 0.0639
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 1231 80 0.3453 0.3687 0.0650 0.0639
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 644 42 0.1806 0.3687 0.0652 0.0639
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 1011 281 0.2190 0.2578 0.2779 0.2624
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 1084 274 0.2430 0.2578 0.2528 0.2624
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 1396 358 0.3114 0.2578 0.2564 0.2624
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 999 239 0.2280 0.2663 0.2392 0.2265
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1072 256 0.2448 0.2663 0.2388 0.2265
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1361 274 0.3261 0.2663 0.2013 0.2265
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 986 130 0.2568 0.1797 0.1318 0.1476
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 703 115 0.1764 0.1797 0.1636 0.1476
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 414 61 0.1059 0.1797 0.1473 0.1476
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 948 133 0.2445 0.1670 0.1403 0.1411
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 644 73 0.1713 0.1670 0.1134 0.1411
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 342 58 0.0852 0.1670 0.1696 0.1411
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 950 329 0.1863 0.2650 0.3463 0.3778