Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 379 111 0.2653 0.3977 0.2929 0.3010
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 509 238 0.2683 0.3271 0.4676 0.4508
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 620 276 0.3406 0.3271 0.4452 0.4508
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 671 295 0.3723 0.3271 0.4396 0.4508
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 460 161 0.2960 0.3366 0.3500 0.3769
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 606 254 0.3485 0.3366 0.4191 0.3769
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 578 209 0.3653 0.3366 0.3616 0.3769
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 655 239 0.4119 0.3026 0.3649 0.3593
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 454 165 0.2861 0.3026 0.3634 0.3593
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 326 114 0.2099 0.3026 0.3497 0.3593
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 521 169 0.3485 0.3073 0.3244 0.3388
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 491 159 0.3287 0.3073 0.3238 0.3388
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 391 144 0.2446 0.3073 0.3683 0.3388
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 463 220 0.2406 0.2776 0.4752 0.4770
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 578 267 0.3079 0.2776 0.4619 0.4770
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 567 280 0.2842 0.2776 0.4938 0.4770
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 332 120 0.2099 0.1957 0.3614 0.3941
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 311 137 0.1723 0.1957 0.4405 0.3941
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 334 127 0.2050 0.1957 0.3802 0.3941
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 571 189 0.3782 0.2512 0.3310 0.3722
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 381 151 0.2277 0.2512 0.3963 0.3722
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 244 95 0.1475 0.2512 0.3893 0.3722
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 418 158 0.2574 0.2033 0.3780 0.3455
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 289 92 0.1950 0.2033 0.3183 0.3455
MMAC-SF Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 241 82 0.1574 0.2033 0.3402 0.3455