Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 1294 292 0.2464 0.2350 0.2257 0.2157
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 2 1419 333 0.2670 0.2350 0.2347 0.2157
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 3 958 179 0.1916 0.2350 0.1868 0.2157
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 1 1333 677 0.1613 0.1889 0.5079 0.5233
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 2 1692 878 0.2002 0.1889 0.5189 0.5233
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 3 1828 993 0.2053 0.1889 0.5432 0.5233
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 1 971 347 0.1534 0.1721 0.3574 0.3456
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 2 1093 381 0.1751 0.1721 0.3486 0.3456
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 3 1142 378 0.1879 0.1721 0.3310 0.3456
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 2090 596 0.3674 0.2822 0.2852 0.2832
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 2 1606 432 0.2887 0.2822 0.2690 0.2832
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 3 1100 325 0.1906 0.2822 0.2955 0.2832
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 1 1087 277 0.1992 0.1899 0.2548 0.2371
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 2 991 237 0.1854 0.1899 0.2392 0.2371
MZ7-mel Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 3 962 209 0.1852 0.1899 0.2173 0.2371
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 3185 192 1.0230 1.0000 0.0603 0.0678
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 3301 210 1.0565 1.0000 0.0636 0.0678
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 2926 233 0.9205 1.0000 0.0796 0.0678
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 2836 228 0.8914 1.4565 0.0804 0.0668
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 4494 264 1.4458 1.4565 0.0587 0.0668
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 6335 389 2.0324 1.4565 0.0614 0.0668
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2786 159 0.8979 0.7564 0.0571 0.0560
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2389 127 0.7732 0.7564 0.0532 0.0560
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 1857 107 0.5982 0.7564 0.0576 0.0560
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 4890 315 1.5637 1.0367 0.0644 0.0669