Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 3 1239 266 0.2393 0.2970 0.2147 0.1997
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 1 1855 354 0.3691 0.3018 0.1908 0.1866
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 1478 267 0.2978 0.3018 0.1806 0.1866
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 3 1195 225 0.2385 0.3018 0.1883 0.1866
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 1 1368 576 0.1948 0.2168 0.4211 0.4113
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 2 1581 673 0.2233 0.2168 0.4257 0.4113
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 3 1542 597 0.2324 0.2168 0.3872 0.4113
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 1 1473 472 0.2461 0.2727 0.3204 0.3250
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 2 1601 554 0.2575 0.2727 0.3460 0.3250
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 3 1850 571 0.3145 0.2727 0.3086 0.3250
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 1 1940 482 0.3585 0.2934 0.2485 0.2564
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 2 1591 425 0.2867 0.2934 0.2671 0.2564
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 3 1281 325 0.2351 0.2934 0.2537 0.2564
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 1 1427 322 0.2717 0.2620 0.2256 0.2154
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 2 1477 316 0.2855 0.2620 0.2139 0.2154
MZ7-mel Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 3 1172 242 0.2287 0.2620 0.2065 0.2154
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 1 1426 673 0.1852 0.2157 0.4719 0.4582
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 2 1603 699 0.2223 0.2157 0.4361 0.4582
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 3 1826 852 0.2395 0.2157 0.4666 0.4582
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 1 1243 414 0.2039 0.2253 0.3331 0.3280
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 2 1380 433 0.2329 0.2253 0.3138 0.3280
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 3 1468 495 0.2393 0.2253 0.3372 0.3280
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 1 1909 485 0.3502 0.2901 0.2541 0.2599
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 2 1527 390 0.2796 0.2901 0.2554 0.2599
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 3 1340 362 0.2405 0.2901 0.2701 0.2599