Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 2 1177 573 0.1592 0.1575 0.4868 0.4835
MZ7-mel Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 3 665 336 0.0867 0.1575 0.5053 0.4835
MZ7-mel Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 1 729 332 0.1046 0.0835 0.4554 0.4574
MZ7-mel Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 2 608 291 0.0835 0.0835 0.4786 0.4574
MZ7-mel Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 3 420 184 0.0622 0.0835 0.4381 0.4574
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 1 4028 208 0.9393 1.0000 0.0516 0.0567
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 2 4820 287 1.1147 1.0000 0.0595 0.0567
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 3 4088 241 0.9460 1.0000 0.0590 0.0567
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 1 5047 236 1.1830 1.2673 0.0468 0.0549
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 2 5542 297 1.2898 1.2673 0.0536 0.0549
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 3 5776 371 1.3291 1.2673 0.0642 0.0549
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 3626 224 0.8366 0.8065 0.0618 0.0577
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 2 3596 201 0.8348 0.8065 0.0559 0.0577
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 3 3220 178 0.7480 0.8065 0.0553 0.0577
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 3.1600
uM
 72
hr
 1 2209 149 0.5066 0.4389 0.0675 0.0642
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 3.1600
uM
 72
hr
 2 2005 133 0.4603 0.4389 0.0663 0.0642
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 3.1600
uM
 72
hr
 3 1511 89 0.3497 0.4389 0.0589 0.0642
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 0.0000
uM
 72
hr
 1 1154 356 0.1962 0.2371 0.3085 0.3065
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 0.0000
uM
 72
hr
 2 1501 424 0.2648 0.2371 0.2825 0.3065
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 0.0000
uM
 72
hr
 3 1516 498 0.2503 0.2371 0.3285 0.3065
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 0.3160
uM
 72
hr
 1 1633 429 0.2961 0.3189 0.2627 0.2566
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 0.3160
uM
 72
hr
 2 1847 436 0.3470 0.3189 0.2361 0.2566
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 0.3160
uM
 72
hr
 3 1749 474 0.3135 0.3189 0.2710 0.2566
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 1 1706 333 0.3376 0.2970 0.1952 0.1997
MZ7-mel Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 2 1575 298 0.3140 0.2970 0.1892 0.1997