Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 340 166 0.1504 0.1236 0.4882 0.4924
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 2 304 159 0.1254 0.1236 0.5230 0.4924
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 3 206 96 0.0951 0.1236 0.4660 0.4924
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 1 471 190 0.2429 0.2490 0.4034 0.4132
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 2 496 204 0.2524 0.2490 0.4113 0.4132
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 3 506 215 0.2516 0.2490 0.4249 0.4132
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 1 324 139 0.1599 0.1631 0.4290 0.3920
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 2 303 130 0.1496 0.1631 0.4290 0.3920
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 3 305 97 0.1798 0.1631 0.3180 0.3920
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 436 186 0.2161 0.1628 0.4266 0.4419
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 2 356 167 0.1634 0.1628 0.4691 0.4419
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 3 221 95 0.1089 0.1628 0.4299 0.4419
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 1 218 86 0.1141 0.1014 0.3945 0.4221
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 2 203 82 0.1046 0.1014 0.4039 0.4221
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 3 186 87 0.0856 0.1014 0.4677 0.4221
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 831 38 0.7851 1.0000 0.0457 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 1129 54 1.0644 1.0000 0.0478 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 1203 41 1.1505 1.0000 0.0341 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1256 52 1.1921 1.3614 0.0414 0.0486
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1549 78 1.4564 1.3614 0.0504 0.0486
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1533 83 1.4356 1.3614 0.0541 0.0486
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 945 46 0.8901 0.7459 0.0487 0.0510
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 873 43 0.8218 0.7459 0.0493 0.0510
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 562 31 0.5257 0.7459 0.0552 0.0510
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 1004 46 0.9485 0.7521 0.0458 0.0500