Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 500 135 0.1248 0.2137 0.2700 0.2920
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 883 391 0.1682 0.2605 0.4428 0.4310
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1367 546 0.2806 0.2605 0.3994 0.4310
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1772 799 0.3326 0.2605 0.4509 0.4310
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 766 308 0.1565 0.1810 0.4021 0.4056
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 846 358 0.1668 0.1810 0.4232 0.4056
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 1057 414 0.2198 0.1810 0.3917 0.4056
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1815 734 0.3695 0.2440 0.4044 0.3869
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1136 396 0.2529 0.2440 0.3486 0.3869
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 542 221 0.1097 0.2440 0.4077 0.3869
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 905 331 0.1962 0.1695 0.3657 0.3471
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 909 315 0.2030 0.1695 0.3465 0.3471
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 477 157 0.1094 0.1695 0.3291 0.3471
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 847 477 0.1265 0.2121 0.5632 0.5496
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 1405 786 0.2116 0.2121 0.5594 0.5496
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 1842 969 0.2984 0.2121 0.5261 0.5496
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 434 189 0.0837 0.0851 0.4355 0.4580
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 533 246 0.0981 0.0851 0.4615 0.4580
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 411 196 0.0735 0.0851 0.4769 0.4580
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1815 982 0.2847 0.1764 0.5410 0.5527
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1121 589 0.1818 0.1764 0.5254 0.5527
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 448 265 0.0625 0.1764 0.5915 0.5527
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 427 202 0.0769 0.0668 0.4731 0.4989
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 390 189 0.0687 0.0668 0.4846 0.4989
MZ7-mel Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 347 187 0.0547 0.0668 0.5389 0.4989