Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 1 1104 933 0.0420 0.0411 0.8451 0.8294
COLO 858 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 2 1075 933 0.0348 0.0411 0.8679 0.8294
COLO 858 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 3 841 652 0.0464 0.0411 0.7753 0.8294
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 0.0000
uM
 72
hr
 1 919 635 0.0697 0.0658 0.6910 0.6842
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 0.0000
uM
 72
hr
 2 799 557 0.0594 0.0658 0.6971 0.6842
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 0.0000
uM
 72
hr
 3 829 551 0.0682 0.0658 0.6647 0.6842
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 1.0000
uM
 72
hr
 1 903 750 0.0375 0.0356 0.8306 0.8419
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 1.0000
uM
 72
hr
 2 905 762 0.0351 0.0356 0.8420 0.8419
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 1.0000
uM
 72
hr
 3 946 807 0.0341 0.0356 0.8531 0.8419
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 1 830 691 0.0341 0.0282 0.8325 0.8552
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 2 760 668 0.0226 0.0282 0.8789 0.8552
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 3 781 667 0.0280 0.0282 0.8540 0.8552
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 1 761 664 0.0238 0.0332 0.8725 0.8226
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 2 802 672 0.0319 0.0332 0.8379 0.8226
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 3 738 559 0.0439 0.0332 0.7575 0.8226
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 0.0000
uM
 72
hr
 1 3564 185 0.9687 1.0000 0.0519 0.0570
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 0.0000
uM
 72
hr
 2 3824 234 1.0291 1.0000 0.0612 0.0570
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 0.0000
uM
 72
hr
 3 3711 215 1.0022 1.0000 0.0579 0.0570
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 1 2490 221 0.6505 0.6307 0.0888 0.0825
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 2 2431 184 0.6441 0.6307 0.0757 0.0825
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 3 2273 189 0.5974 0.6307 0.0832 0.0825
WM-115 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 0.0000
uM
 72
hr
 1 1834 447 0.3976 0.4192 0.2437 0.2367
WM-115 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 0.0000
uM
 72
hr
 2 2021 446 0.4515 0.4192 0.2207 0.2367
WM-115 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 0.0000
uM
 72
hr
 3 1889 464 0.4085 0.4192 0.2456 0.2367
WM-115 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 1 1215 837 0.1084 0.1000 0.6889 0.6967