Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 2 1213 834 0.1086 0.1000 0.6876 0.6967
WM-115 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 3 1013 723 0.0831 0.1000 0.7137 0.6967
WM-115 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 0.0000
uM
 72
hr
 1 1679 452 0.3517 0.3470 0.2692 0.2781
WM-115 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 0.0000
uM
 72
hr
 2 1650 476 0.3366 0.3470 0.2885 0.2781
WM-115 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 0.0000
uM
 72
hr
 3 1700 470 0.3526 0.3470 0.2765 0.2781
WM-115 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 1.0000
uM
 72
hr
 1 994 715 0.0800 0.0771 0.7193 0.7216
WM-115 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 1.0000
uM
 72
hr
 2 975 736 0.0685 0.0771 0.7549 0.7216
WM-115 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 1.0000
uM
 72
hr
 3 934 645 0.0828 0.0771 0.6906 0.7216
WM-115 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 0.0000
uM
 72
hr
 1 1493 501 0.2844 0.2945 0.3356 0.3359
WM-115 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 0.0000
uM
 72
hr
 2 1521 489 0.2958 0.2945 0.3215 0.3359
WM-115 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 0.0000
uM
 72
hr
 3 1629 571 0.3033 0.2945 0.3505 0.3359
WM-115 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 1.0000
uM
 72
hr
 1 1012 808 0.0585 0.0595 0.7984 0.7824
WM-115 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 1.0000
uM
 72
hr
 2 913 707 0.0591 0.0595 0.7744 0.7824
WM-115 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 1.0000
uM
 72
hr
 3 944 731 0.0611 0.0595 0.7744 0.7824
WM-115 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 0.0000
uM
 72
hr
 1 1356 667 0.1975 0.1988 0.4919 0.4946
WM-115 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 0.0000
uM
 72
hr
 2 1386 670 0.2053 0.1988 0.4834 0.4946
WM-115 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 0.0000
uM
 72
hr
 3 1373 698 0.1935 0.1988 0.5084 0.4946
WM-115 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 1.0000
uM
 72
hr
 1 909 744 0.0473 0.0511 0.8185 0.8071
WM-115 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 1.0000
uM
 72
hr
 2 967 770 0.0565 0.0511 0.7963 0.8071
WM-115 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 1.0000
uM
 72
hr
 3 894 721 0.0496 0.0511 0.8065 0.8071
WM-115 Vemurafenib Trametinib Belinostat 0.0000 0.0000 0.0000
uM
 72
hr
 1 3696 192 1.0244 1.0000 0.0519 0.0594
WM-115 Vemurafenib Trametinib Belinostat 0.0000 0.0000 0.0000
uM
 72
hr
 2 3441 211 0.9443 1.0000 0.0613 0.0594
WM-115 Vemurafenib Trametinib Belinostat 0.0000 0.0000 0.0000
uM
 72
hr
 3 3773 245 1.0314 1.0000 0.0649 0.0594
WM-115 Vemurafenib Trametinib Belinostat 0.0000 0.0000 1.0000
uM
 72
hr
 1 1768 214 0.4543 0.4681 0.1210 0.0978
WM-115 Vemurafenib Trametinib Belinostat 0.0000 0.0000 1.0000
uM
 72
hr
 2 1824 165 0.4850 0.4681 0.0905 0.0978