Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Belinostat 0.0000 0.0000 1.0000
uM
 72
hr
 3 1733 142 0.4651 0.4681 0.0819 0.0978
WM-115 Vemurafenib Trametinib Belinostat 0.1000 0.0100 0.0000
uM
 72
hr
 1 1991 518 0.4306 0.4346 0.2602 0.2416
WM-115 Vemurafenib Trametinib Belinostat 0.1000 0.0100 0.0000
uM
 72
hr
 2 1998 469 0.4470 0.4346 0.2347 0.2416
WM-115 Vemurafenib Trametinib Belinostat 0.1000 0.0100 0.0000
uM
 72
hr
 3 1893 435 0.4262 0.4346 0.2298 0.2416
WM-115 Vemurafenib Trametinib Belinostat 0.1000 0.0100 1.0000
uM
 72
hr
 1 1048 427 0.1815 0.1762 0.4074 0.3974
WM-115 Vemurafenib Trametinib Belinostat 0.1000 0.0100 1.0000
uM
 72
hr
 2 1046 423 0.1821 0.1762 0.4044 0.3974
WM-115 Vemurafenib Trametinib Belinostat 0.1000 0.0100 1.0000
uM
 72
hr
 3 910 346 0.1649 0.1762 0.3802 0.3974
WM-115 Vemurafenib Trametinib Belinostat 0.3160 0.0316 0.0000
uM
 72
hr
 1 1691 554 0.3324 0.3393 0.3276 0.3184
WM-115 Vemurafenib Trametinib Belinostat 0.3160 0.0316 0.0000
uM
 72
hr
 2 1659 510 0.3359 0.3393 0.3074 0.3184
WM-115 Vemurafenib Trametinib Belinostat 0.3160 0.0316 0.0000
uM
 72
hr
 3 1759 563 0.3496 0.3393 0.3201 0.3184
WM-115 Vemurafenib Trametinib Belinostat 0.3160 0.0316 1.0000
uM
 72
hr
 1 722 289 0.1266 0.1313 0.4003 0.4367
WM-115 Vemurafenib Trametinib Belinostat 0.3160 0.0316 1.0000
uM
 72
hr
 2 839 376 0.1354 0.1313 0.4482 0.4367
WM-115 Vemurafenib Trametinib Belinostat 0.3160 0.0316 1.0000
uM
 72
hr
 3 838 387 0.1318 0.1313 0.4618 0.4367
WM-115 Vemurafenib Trametinib Belinostat 1.0000 0.1000 0.0000
uM
 72
hr
 1 1709 621 0.3181 0.3255 0.3634 0.3464
WM-115 Vemurafenib Trametinib Belinostat 1.0000 0.1000 0.0000
uM
 72
hr
 2 1678 577 0.3219 0.3255 0.3439 0.3464
WM-115 Vemurafenib Trametinib Belinostat 1.0000 0.1000 0.0000
uM
 72
hr
 3 1723 572 0.3365 0.3255 0.3320 0.3464
WM-115 Vemurafenib Trametinib Belinostat 1.0000 0.1000 1.0000
uM
 72
hr
 1 753 383 0.1082 0.1223 0.5086 0.4835
WM-115 Vemurafenib Trametinib Belinostat 1.0000 0.1000 1.0000
uM
 72
hr
 2 838 403 0.1272 0.1223 0.4809 0.4835
WM-115 Vemurafenib Trametinib Belinostat 1.0000 0.1000 1.0000
uM
 72
hr
 3 835 385 0.1316 0.1223 0.4611 0.4835
WM-115 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 1 1395 752 0.1880 0.1808 0.5391 0.5357
WM-115 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 2 1290 683 0.1775 0.1808 0.5295 0.5357
WM-115 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 3 1311 706 0.1769 0.1808 0.5385 0.5357
WM-115 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 1 693 390 0.0886 0.0918 0.5628 0.5675
WM-115 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 2 761 430 0.0968 0.0918 0.5650 0.5675
WM-115 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 3 724 416 0.0900 0.0918 0.5746 0.5675