Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib JNK-IN-8 3.160 0.316
uM
 72
hr
 3 411 106 0.2995 0.2619 0.2579 0.2293
MMAC-SF Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 3 413 82 0.3351 0.4489 0.1985 0.1849
MMAC-SF Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 1 413 133 0.2835 0.2531 0.3220 0.3208
MMAC-SF Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 2 414 180 0.1442 0.1471 0.4348 0.4142
COLO 858 Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 3 422 406 0.0029 0.0041 0.9621 0.9488
COLO 858 Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 2 424 402 0.0040 0.0041 0.9481 0.9488
MMAC-SF Vemurafenib JNK-IN-8 0.316 3.160
uM
 72
hr
 3 430 50 0.3732 0.6000 0.1163 0.1021
MMAC-SF Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 1 431 171 0.1602 0.1471 0.3968 0.4142
MMAC-SF Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 2 434 114 0.2553 0.2628 0.2627 0.2739
MMAC-SF Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 3 443 169 0.1688 0.2245 0.3815 0.3979
MZ7-mel Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 2 446 136 0.0983 0.1027 0.3049 0.2808
MZ7-mel Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 1 447 138 0.1008 0.1000 0.3087 0.3467
MMAC-SF Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 451 88 0.2780 0.2918 0.1951 0.1993
MMAC-SF Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 3 451 21 0.4354 0.6021 0.0466 0.0426
MMAC-SF Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 1 453 159 0.1811 0.1801 0.3510 0.3728
MMAC-SF Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 2 454 186 0.1651 0.1742 0.4097 0.4178
MMAC-SF Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 3 459 176 0.1744 0.1801 0.3834 0.3728
MZ7-mel Vemurafenib JNK-IN-8 1.000 1.000
uM
 72
hr
 3 460 65 0.1252 0.3116 0.1413 0.1548
MMAC-SF Vemurafenib JNK-IN-8 3.160 1.000
uM
 72
hr
 2 462 141 0.3152 0.3656 0.3052 0.2907
MMAC-SF Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 2 465 150 0.2413 0.2538 0.3226 0.3464
MMAC-SF Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 471 92 0.2903 0.2918 0.1953 0.1993
COLO 858 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 3 471 427 0.0079 0.0109 0.9066 0.8930
MMAC-SF Vemurafenib Dasatinib 1.000 3.160
uM
 72
hr
 3 471 57 0.3171 0.4386 0.1210 0.1472
MMAC-SF Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 2 472 162 0.3139 0.3044 0.3432 0.3533
MMAC-SF Vemurafenib JNK-IN-8 1.000 3.160
uM
 72
hr
 3 473 85 0.3810 0.4579 0.1797 0.1782