Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | Belinostat | 0.000 | 1.000 | uM | 72 | hr | 3 | 1730 | 123 | 0.4608 | 0.4993 | 0.0711 | 0.0637 |
| WM-115 | Vemurafenib | Belinostat | 0.100 | 0.000 | uM | 72 | hr | 1 | 3106 | 146 | 0.8487 | 0.8519 | 0.0470 | 0.0498 |
| WM-115 | Vemurafenib | Belinostat | 0.100 | 0.000 | uM | 72 | hr | 2 | 3138 | 175 | 0.8496 | 0.8519 | 0.0558 | 0.0498 |
| WM-115 | Vemurafenib | Belinostat | 0.100 | 0.000 | uM | 72 | hr | 3 | 3136 | 146 | 0.8573 | 0.8519 | 0.0466 | 0.0498 |
| WM-115 | Vemurafenib | Belinostat | 0.100 | 1.000 | uM | 72 | hr | 1 | 1536 | 159 | 0.3948 | 0.3982 | 0.1035 | 0.1124 |
| WM-115 | Vemurafenib | Belinostat | 0.100 | 1.000 | uM | 72 | hr | 2 | 1564 | 184 | 0.3957 | 0.3982 | 0.1176 | 0.1124 |
| WM-115 | Vemurafenib | Belinostat | 0.100 | 1.000 | uM | 72 | hr | 3 | 1594 | 185 | 0.4040 | 0.3982 | 0.1161 | 0.1124 |
| WM-115 | Vemurafenib | Belinostat | 0.316 | 0.000 | uM | 72 | hr | 1 | 2610 | 214 | 0.6870 | 0.7002 | 0.0820 | 0.0767 |
| WM-115 | Vemurafenib | Belinostat | 0.316 | 0.000 | uM | 72 | hr | 2 | 2666 | 216 | 0.7025 | 0.7002 | 0.0810 | 0.0767 |
| WM-115 | Vemurafenib | Belinostat | 0.316 | 0.000 | uM | 72 | hr | 3 | 2658 | 178 | 0.7111 | 0.7002 | 0.0670 | 0.0767 |
| WM-115 | Vemurafenib | Belinostat | 0.316 | 1.000 | uM | 72 | hr | 1 | 1440 | 235 | 0.3455 | 0.3608 | 0.1632 | 0.1482 |
| WM-115 | Vemurafenib | Belinostat | 0.316 | 1.000 | uM | 72 | hr | 2 | 1526 | 179 | 0.3862 | 0.3608 | 0.1173 | 0.1482 |
| WM-115 | Vemurafenib | Belinostat | 0.316 | 1.000 | uM | 72 | hr | 3 | 1463 | 240 | 0.3507 | 0.3608 | 0.1640 | 0.1482 |
| WM-115 | Vemurafenib | Belinostat | 1.000 | 0.000 | uM | 72 | hr | 1 | 2314 | 307 | 0.5755 | 0.6049 | 0.1327 | 0.1230 |
| WM-115 | Vemurafenib | Belinostat | 1.000 | 0.000 | uM | 72 | hr | 2 | 2422 | 282 | 0.6136 | 0.6049 | 0.1164 | 0.1230 |
| WM-115 | Vemurafenib | Belinostat | 1.000 | 0.000 | uM | 72 | hr | 3 | 2479 | 297 | 0.6256 | 0.6049 | 0.1198 | 0.1230 |
| WM-115 | Vemurafenib | Belinostat | 1.000 | 1.000 | uM | 72 | hr | 1 | 1261 | 288 | 0.2790 | 0.2809 | 0.2284 | 0.2175 |
| WM-115 | Vemurafenib | Belinostat | 1.000 | 1.000 | uM | 72 | hr | 2 | 1328 | 282 | 0.2999 | 0.2809 | 0.2123 | 0.2175 |
| WM-115 | Vemurafenib | Belinostat | 1.000 | 1.000 | uM | 72 | hr | 3 | 1167 | 247 | 0.2638 | 0.2809 | 0.2117 | 0.2175 |
| WM-115 | Vemurafenib | Belinostat | 3.160 | 0.000 | uM | 72 | hr | 1 | 1849 | 406 | 0.4137 | 0.4271 | 0.2196 | 0.2254 |
| WM-115 | Vemurafenib | Belinostat | 3.160 | 0.000 | uM | 72 | hr | 2 | 1953 | 461 | 0.4278 | 0.4271 | 0.2360 | 0.2254 |
| WM-115 | Vemurafenib | Belinostat | 3.160 | 0.000 | uM | 72 | hr | 3 | 1968 | 434 | 0.4398 | 0.4271 | 0.2205 | 0.2254 |
| WM-115 | Vemurafenib | Belinostat | 3.160 | 1.000 | uM | 72 | hr | 1 | 1011 | 319 | 0.1984 | 0.1972 | 0.3155 | 0.3280 |
| WM-115 | Vemurafenib | Belinostat | 3.160 | 1.000 | uM | 72 | hr | 2 | 1044 | 347 | 0.1998 | 0.1972 | 0.3324 | 0.3280 |
| WM-115 | Vemurafenib | Belinostat | 3.160 | 1.000 | uM | 72 | hr | 3 | 1015 | 341 | 0.1933 | 0.1972 | 0.3360 | 0.3280 |